15q13-15 Rearrangements
2003-09-01 Nyla A Heerema Affiliation1.The Ohio State University, Division of Clinical Pathology, Department of Pathology, 167 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA
Clinics and Pathology
Disease
Phenotype stem cell origin
Most ALL are B-lineage, few T-lineage.
AML: most subtypes.
CML:
Lymphomas: described in follicular, diffuse large B-cell, mantle cell and anaplastic large cell, as well as Hodgkin lymphomas.
AML: most subtypes.
CML:
Lymphomas: described in follicular, diffuse large B-cell, mantle cell and anaplastic large cell, as well as Hodgkin lymphomas.
Epidemiology
Rare in childhood ALL (about 1%), more common in infant ALL (about 13%).
Very rare in AML, adult ALL, CLL and lymphomas.
Occurs in primary and secondary leukemias.
CML: rare, occurs as secondary abnormality or part of complex Ph rearrangement
Very rare in AML, adult ALL, CLL and lymphomas.
Occurs in primary and secondary leukemias.
CML: rare, occurs as secondary abnormality or part of complex Ph rearrangement
Prognosis
Childhood ALL: No increased risk with current treatment regimens. Outcome not described in other diseases.
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8161794 | 1994 | Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group. | Heerema NA et al |
| 9454771 | 1998 | Fluorescence in situ hybridization characterization of new translocations involving TEL (ETV6) in a wide spectrum of hematologic malignancies. | Wlodarska I et al |
Citation
Nyla A Heerema
15q13-15 Rearrangements
Atlas Genet Cytogenet Oncol Haematol. 2003-09-01
Online version: http://atlasgeneticsoncology.org/haematological/1257/15q13-15-rearrangements
