15q13-15 Rearrangements

2003-09-01   Nyla A Heerema 

1.The Ohio State University, Division of Clinical Pathology, Department of Pathology, 167 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA

Clinics and Pathology

Disease

Acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CML), chronic lymphocytic leukemia (CLL) and non Hodgkin lymphomas (NHL).

Phenotype stem cell origin

Most ALL are B-lineage, few T-lineage.
AML: most subtypes.
CML:
Lymphomas: described in follicular, diffuse large B-cell, mantle cell and anaplastic large cell, as well as Hodgkin lymphomas.

Epidemiology

Rare in childhood ALL (about 1%), more common in infant ALL (about 13%).
Very rare in AML, adult ALL, CLL and lymphomas.
Occurs in primary and secondary leukemias.
CML: rare, occurs as secondary abnormality or part of complex Ph rearrangement

Prognosis

Childhood ALL: No increased risk with current treatment regimens. Outcome not described in other diseases.

Bibliography

Pubmed IDLast YearTitleAuthors
81617941994Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group.Heerema NA et al
94547711998Fluorescence in situ hybridization characterization of new translocations involving TEL (ETV6) in a wide spectrum of hematologic malignancies.Wlodarska I et al

Citation

Nyla A Heerema

15q13-15 Rearrangements

Atlas Genet Cytogenet Oncol Haematol. 2003-09-01

Online version: http://atlasgeneticsoncology.org/haematological/1257/15q13-15-rearrangements