1.Department of Pathology, Peking University Peoples Hospital, Beijing 100044, Peoples Republic of China; cdingbao@163.com
Tumours derived from Langerhans cells (LCs) are divided into two main subgroups, according to the degree of cytological atypia and clinical aggressiveness: LC histiocytosis (LCH) and LC sarcoma. Both subgroups maintain the phenotypic profile and ultrastructural features of LCs. LCH is a clonal neoplastic proliferation of Langerhans-type cells that express CD1a, langerin, and S100 protein, showing Birbeck granules by ultrastructural examination. Here the clinicopathological of LCH will be discussed.
Ding-Bao Chen
Langerhans cell histiocytosis
Atlas Genet Cytogenet Oncol Haematol. 2019-06-01
Online version: http://atlasgeneticsoncology.org/haematological/1730/langerhans-cell-histiocytosis