inv(12)(q13q13) NAB2/STAT6

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Solitary fibrous tumor

Genes Involved and Proteins

Gene name
NAB2
Location
12q13.3
Gene name
STAT6
Location
12q13.3

Highly cited references

Pubmed IDYearTitleCitations
327961722021The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?39
296605662018Extrapleural solitary fibrous tumor: A distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features.39
306037302018Solitary fibrous tumor.35
305846432019The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.14
313214772019Molecular changes in solitary fibrous tumor progression.13
304311442019Solitary fibrous tumor: An evolving and unifying entity with unsettled issues.13
286440982018Intracranial solitary fibrous tumors/hemangiopericytomas: first report of malignant progression.11
315291582020Solitary fibrous tumor: a case series identifying pathological adverse factors-implications for risk stratification and classification.10
342009242021A Comprehensive Review on Solitary Fibrous Tumor: New Insights for New Horizons.8
314637292020Histological and molecular features of solitary fibrous tumor of the extremities: clinical correlation.7
302142282018Surgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura.7
292288682018Solitary Fibrous Tumors in Pediatric Patients: A Rare and Potentially Overdiagnosed Neoplasm, Confirmed by STAT6 Immunohistochemistry.7
334977012021Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants.6
306645322020STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience.6
306233052020Recurrent Sinonasal CD34-Negative Malignant Solitary Fibrous Tumor Diagnosed on STAT6 Immunohistochemistry and NAB2-STAT6 Fusion.6
313924682019Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death.6
296005232019Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients.6
293098072018Solitary fibrous tumor with neuroendocrine and squamous dedifferentiation: a potential diagnostic pitfall.6
337457022021Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour.5
338792152021The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.5
321969652020Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4-STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report.5
310204642019Solitary fibrous tumor in the liver: case report and literature review.5
307614202019Prognostic significance of NAB2-STAT6 fusion variants and TERT promotor mutations in solitary fibrous tumors/hemangiopericytomas of the CNS: not (yet) clear.5
322169682020NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation.4
322170902020Solitary fibrous tumors of the head and neck region revisited: a single-institution study of 20 cases and review of the literature.3
297006732018Pazopanib efficacy in recurrent central nervous system hemangiopericytomas.3
297037572018Telomerase promoter mutations and copy number alterations in solitary fibrous tumours.3
306938812018Reappraisal of morphological and immunohistochemical spectrum of intracranial and spinal solitary fibrous tumors/hemangiopericytomas with impact on long-term follow-up.3
352058122022Novel Therapeutic Options for Solitary Fibrous Tumor: Antiangiogenic Therapy and Beyond.2
339864602021Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes.2
338872152021Lipomatous Solitary Fibrous Tumors Harbor Rare NAB2-STAT6 Fusion Variants and Show Up-Regulation of the Gene PPARG, Encoding for a Regulator of Adipocyte Differentiation.2
339766222021Doege-Potter Syndrome with a Benign Solitary Fibrous Tumor: A Case Report and Literature Review.2
328437652020Recurrence of Solitary Fibrous Tumor/Hemangiopericytoma Could Be Predicted by Ki-67 Regardless of Its Origin.2
327937342020Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature.2
325907482020A novel TJP1-ROS1 fusion in malignant peripheral nerve sheath tumor responding to crizotinib: A case report.2
314241362020Solitary fibrous tumour of the oral cavity: An update.2
312714322019Papillary Solitary Fibrous Tumor/Hemangiopericytoma: An Uncommon Morphological Form With NAB2-STAT6 Gene Fusion.2
303606652019Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature.2
289682972018Solitary Fibrous Tumor of the Vulva: Report of 2 Cases, Including a De Novo Dedifferentiated Solitary Fibrous Tumor Diagnosed After Molecular Demonstration of NAB2-STAT6 Gene Fusion.2
306437642018Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma.2
352381182022Development and validation of an RNA sequencing panel for gene fusions in soft tissue sarcoma.1
340753962021NAB2-STAT6 Gene Fusions to Evaluate Primary/Metastasis of Hemangiopericytoma/Solitary Fibrous Tumors.1
344177112021Molecular description of meningeal solitary fibrous tumors/hemangiopericytomas compared to meningiomas: two completely separate entities.1
345023292021Solitary Fibrous Tumor: Integration of Clinical, Morphologic, Immunohistochemical and Molecular Findings in Risk Stratification and Classification May Better Predict Patient outcome.1
342991332021A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report.1
337999992021Solitary Fibrous Tumor/Hemangiopericytoma Metastasizes Extracranially, Associated with Altered Expression of WNT5A and MMP9.1
329254442021Solitary Fibrous Tumor of the Vulva: Case Report of a Rare Entity and Review of Literature.1
331606072020[What's new in the management of meningeal solitary fibrous tumor/hemangiopericytoma?]1
318790782020Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations.1
329722782020Solitary fibrous tumor of the pleura in a 22-year-old woman: a case report.1
319725912020Metastatic intracranial solitary fibrous tumors/hemangiopericytomas: description of two cases with radically different behaviors and review of the literature.1
314902352019Meningioma-like Tumor of the Skin Revisited: A Distinct CD34+ Dermal Tumor With an Expanded Histologic Spectrum.1
310168892019Cytomorphologic features of malignant solitary fibrous tumor with mediastinal involvement sampled by endoscopic and endobronchial ultrasound-guided fine-needle aspiration: A comparison of two cases.1
311435642019High p16 Expression Is Associated with Malignancy and Shorter Disease-Free Survival Time in Solitary Fibrous Tumor/Hemangiopericytoma.1
298963982018Cytological characteristics of meningeal solitary fibrous tumor metastatic to the lung: A case report with immunocytochemical analysis.1
295592172018Solitary fibrous tumour/haemangiopericytoma of the spinal cord.1
292766852018Bilateral renal involvement by solitary fibrous tumor - Report of a case in the post-WHO/2016 era.1
353032772022Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities?0
358316172022A review of solitary fibrous tumours of the orbit and ocular adnexa.0
357111642022A Rare Case of a Solitary Fibrous Tumor in a Child, Presenting as a Congenital Mass, Displaying NAB2ex4::STAT6ex2 Gene Fusion with an Incidental Ganglioneuroblastoma.0
359933542022Solitary Fibrous Tumor of the Adrenal Gland.0
359656422022Expression of p53 as a biomarker of pazopanib efficacy in solitary fibrous tumours: translational analysis of a phase II trial.0
359533912022Solitary fibrous tumor: A rare lesion with an unusual paravertebral presentation.0
357582002022Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene.0
351955772022Misleading Morphologic and Phenotypic Features (Transdifferentiation) in Solitary Fibrous Tumor of the Head and Neck: Report of 3 Cases and Review of the Literature.0
357798872022[Fat-forming solitary fibrous tumor with NAB2/ STAT6 gene fusion. Case report of genial location and literature review].0
357151452022Toward Better Understanding and Management of Solitary Fibrous Tumor.0
349997412022Solitary Fibrous Tumor With Extensive Epithelial Inclusions.0
356737232022[Malignant solitary fibrous tumors: a clinicopathological and molecular genetic analysis].0
350300672022Mesenchymal Neoplasms of the Prostate and Seminal Vesicles: Spectrum of Disease with Radiologic-Pathologic Correlation.0
341646892022Skull Base Tumors: Neuropathology and Clinical Implications.0
354041642022Shapeshifters in Pathology: Paratesticular Solitary Fibrous Tumor Mimicking Leiomyoma.0
352172662022A mesenchymal chondrosarcoma with aberrant nuclear expression of STAT6: a potential diagnostic pitfall.0
351690942022[Solitary fibrous tumor/hemangiopericytoma].0
345511762022Cytopathological characteristics of solitary fibrous tumour involving the pancreas by fine needle aspiration: Making an accurate preoperative diagnosis in an uncommon location.0
349842332021Primary solitary fibrous tumor of the thyroid gland: A review starting from a case report.0
340528672021A case of a large solitary fibrous tumor in the thigh, displaying NAB2ex4-STAT6ex2 gene fusion.0
348180262022Determination of biological behavior of solitary fibrous tumors: correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs.0
346803832021Evaluation of NAB2-STAT6 Fusion Variants and Other Molecular Alterations as Prognostic Biomarkers in a Case Series of 83 Solitary Fibrous Tumors.0
350042712021Case Report: Molecular Characterization of Aggressive Malignant Retroperitoneal Solitary Fibrous Tumor: A Case Study.0
344098592021Solitary fibrous tumor: molecular hallmarks and treatment for a rare sarcoma.0
343048442021Implications of Adverse Biological Factors and Management of Solitary Fibrous Tumors of the Pleura.0
346456302021A rare case of rectal bleeding and Fusobacterium mortiferum sepsis due to solitary fibrous tumour originating from the mesentery.0
344230052021Severe hypoglycemia and finger clubbing in a patient with a BRCA1 mutation in a solitary fibrous tumor: a case report.0
340498412021Cytopathology of solitary fibrous tumor: a series of 34 cases.0
340693782021Clinical, Histological, and Molecular Features of Solitary Fibrous Tumor of Bone: A Single Institution Retrospective Review.0
336667862021Aberrant expression of thyroid transcription factor-1 in meningeal solitary fibrous tumor/hemangiopericytoma.0
334017432021Preoperative Embolization of a Solitary Fibrous Tumor Originating from External Auditory Meatus: A Case Report with Literature Review.0
334334362021A rare case of a solitary fibrous tumor of vulva, displaying NAB2ex6-STAT6ex17 fusion.0
328925562020[Clinicopathological characteristics of myxoid solitary fibrous tumor: analysis of seven cases].0
343749692020Intracranial Solitary Fibrous Tumor/Hemangiopericytoma: A Clinicoradiological Poorly Recognized Entity- An Institutional Experience.0
327407532020A dedifferentiated intracranial solitary fibrous tumor with osteosarcoma components: rapid tumor progression and lethal clinical course.0
323867742020Rare variants of solitary fibrous tumor.0
324429152020Two cases of primary solitary fibrous tumor in the pelvis resected using laparoscopic surgery.0
332541262020[Immunohistochemical analysis for the diagnosis of solitary fibrous tumor/ hemangiopericytoma].0
309407852019[A Case of Meningeal Solitary Fibrous Tumour/Haemangiopericytoma WHO Grade III Metastasized to the Spleen Shortly After Tumor Resection].0
292570412019A Rare Case of a Vaginal Solitary Fibrous Tumor, Presenting as a Cystic Mass, Showing NAB2ex4-STAT6ex2 Fusion and STAT6 Immunostaining.0
306038452019A rapidly fatal intracranial anaplastic hemangiopericytoma with de-novo dedifferentiation: emphasis on diagnostic recognition, molecular confirmation and discussion on treatment dilemma.0
296165972018Malignant Solitary Fibrous Tumor Metastatic to Widely Invasive Hurthle Cell Thyroid Carcinoma: A Distinct Tumor-to-Tumor Metastasis.0
297910182018A rare case of a solitary fibrous tumour of bone showing NAB2-STAT6 exon 3-exon 19 fusion.0

Bibliography

Pubmed IDLast YearTitleAuthors
262268442015NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors.Tai HC et al

Summary

Fusion gene

NAB2/STAT6 NAB2 (12q13.3) STAT6 (12q13.3)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

inv(12)(q13q13) NAB2/STAT6

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2994/inv(12)(q13q13)-nab2-stat6