t(1;21)(p32;q22) RUNX1/NDC1

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute myeloid leukemia, NOS

Genes Involved and Proteins

Gene name
RUNX1
Location
21q22.12
Gene name
NDC1
Location
1p32.3

Bibliography

Pubmed IDLast YearTitleAuthors
257988342016Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors.Rodriguez-Perales S et al

Summary

Fusion gene

RUNX1/NDC1 RUNX1 (21q22.12) NDC1 (1p32.3)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(1;21)(p32;q22) RUNX1/NDC1

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3172/t(1;21)(p32;q22)-runx1-ndc1