t(2;14)(q22;q32) ZEB2/BCL11B

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute myeloid leukemia, NOS

Genes Involved and Proteins

Gene name
ZEB2
Location
2q22.3
Gene name
BCL11B
Location
14q32.2

Highly cited references

Pubmed IDYearTitleCitations
33876209202114q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia.12
318174952019Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia.8
261863522015Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14)(q22;q32).6

Bibliography

Pubmed IDLast YearTitleAuthors
261863522015Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14)(q22;q32).Torkildsen S et al

Summary

Fusion gene

ZEB2/BCL11B ZEB2 (2q22.3) BCL11B (14q32.2)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(2;14)(q22;q32) ZEB2/BCL11B

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3347/t(2;14)(q22;q32)-zeb2-bcl11b