t(2;21)(q11;q22) RUNX1/AFF3

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
Location
21q22.12
Gene name
Location
2q11.2

Bibliography

Pubmed IDLast YearTitleAuthors
179683222008Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA.Chinen Y et al
286716872017Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.Seki M et al

Summary

Fusion gene

RUNX1/AFF3 RUNX1 (21q22.12) AFF3 (2q11.2)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(2;21)(q11;q22) RUNX1/AFF3

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3159/t(2;21)(q11;q22)-runx1-aff3