t(4;14)(q35;q32) DUX4/IGH

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
DUX4
Location
4q35.2
Gene name
IGH
Location
14q32.33

Highly cited references

Pubmed IDYearTitleCitations
274284282016Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.105
270191132016Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults.96
288069782017Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles.16
295725082018Structural basis of DUX4/IGH-driven transactivation.10
320548782020Refined detection and phasing of structural aberrations in pediatric acute lymphoblastic leukemia by linked-read whole-genome sequencing.7
345802922021In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.3
349438342021DUX4 Role in Normal Physiology and in FSHD Muscular Dystrophy.2
346996922021DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.2
300545542018Comment on structural basis of DUX4/IGH-driven transactivation.1
288832662017Acute lymphoblastic leukemia of adolescents and young adults: from the viewpoint of physicians.0

Bibliography

Pubmed IDLast YearTitleAuthors
270191132016Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults.Yasuda T et al

Summary

Fusion gene

DUX4/IGH DUX4 (4q35.2) IGH (14q32.33)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(4;14)(q35;q32) DUX4/IGH

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2670/t(4;14)(q35;q32)-dux4-igh