t(5;17)(p13;q21) NIPBL/HOXB9

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Acute megakaryoblastic leukemia (FAB type M7)

Genes Involved and Proteins

Gene name
NIPBL
Location
5p13.2
Gene name
HOXB9
Location
17q21.32

Highly cited references

Pubmed IDYearTitleCitations
281744172017AMKL chimeric transcription factors are potent inducers of leukemia.16

Bibliography

Pubmed IDLast YearTitleAuthors
231535402012An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.Gruber TA et al
281127372017Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.de Rooij JD et al

Summary

Fusion gene

NIPBL/HOXB9 NIPBL (5p13.2) HOXB9 (17q21.32)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Citation

Jean-Loup Huret ; Philippe Dessen

t(5;17)(p13;q21) NIPBL/HOXB9

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3012/t(5;17)(p13;q21)-nipbl-hoxb9