t(6;14)(p25;q32) IGH/IRF4

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Diffuse large B-cell lymphoma|Follicular lymphoma|Multiple myeloma

Genes Involved and Proteins

Gene name
IGH
Location
14q32.33
Gene name
IRF4
Location
6p25.3

Bibliography

Pubmed IDLast YearTitleAuthors
105570561999Detection of MUM1/IRF4-IgH fusion in multiple myeloma.Yoshida S et al
93269491997Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma.Iida S et al
214871092011Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults.Salaverria I et al
273562652016Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.Otto C et al

Summary

Fusion gene

IGH/IRF4 IGH (14q32.33) IRF4 (6p25.3)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

t(6;14)(p25;q32) IGH/IRF4

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2802/t(6;14)(p25;q32)-igh-irf4