NUP214/ABL1 (9q34)

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
NUP214
Location
9q34.13
Gene name
ABL1
Location
9q34.12

Highly cited references

Pubmed IDYearTitleCitations
153618742004Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.111
204733122010Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.79
157138002005Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).36
215512372011PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.35
214350022011ABL1 fusion genes in hematological malignancies: a review.32
183222572008In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.31
186140522008Kinase activation and transformation by NUP214-ABL1 is dependent on the context of the nuclear pore.29
184014172008Activity of tyrosine kinase inhibitors against human NUP214-ABL1-positive T cell malignancies.27
189876552009Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia.23
301071772018Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.22
189234372009Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.22
200730702010ABL1 rearrangements in T-cell acute lymphoblastic leukemia.21
187847402008Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases.21
251206412014NUP214 fusion genes in acute leukemia (Review).17
238723052014NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins.17
181855242008Cooperative genetic defects in TLX3 rearranged pediatric T-ALL.13
271616582016Genome-Wide Single-Nucleotide Polymorphism Array Analysis Improves Prognostication of Acute Lymphoblastic Leukemia/Lymphoma.12
268643412016Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.12
168736732006NUP214-ABL1 in adult T-ALL: the GMALL study group experience.12
304667482018Can one target T-cell ALL?11
302804912019Clinical and biological relevance of genetic alterations in pediatric T-cell acute lymphoblastic leukemia in Taiwan.11
266817612016NUP214-ABL1 fusion defines a rare subtype of B-cell precursor acute lymphoblastic leukemia that could benefit from tyrosine kinase inhibitors.11
214896232011NUP214-ABL1 positive T-cell acute lymphoblastic leukemia patient shows an initial favorable response to imatinib therapy post relapse.11
278218002016Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia.10
231756622012Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia.10
188358362008Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome.9
166730192006A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia.9
290670942017Dasatinib and chemotherapy in a patient with early T-cell precursor acute lymphoblastic leukemia and NUP214-ABL1 fusion: A case report.8
245336892014Development of detection method for novel fusion gene using GeneChip exon array.7
321429002020Design of a Comprehensive Fluorescence in Situ Hybridization Assay for Genetic Classification of T-Cell Acute Lymphoblastic Leukemia.4
174886852007Characterization of ABL1 expression in adult T-cell acute lymphoblastic leukemia by oligonucleotide array analysis.4
170241112006Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia.3
316222812019A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.2
310141382019Response to single agent dasatinib post allogeneic transplant in B-cell acute lymphoblastic leukemia with NUP214-ABL1.2
309361932019Detection of a cryptic NUP214/ABL1 gene fusion by mate-pair sequencing (MPseq) in a newly diagnosed case of pediatric T-lymphoblastic leukemia.2
292198902018A Cryptic NUP214-ABL1 Fusion in B-cell Precursor Acute Lymphoblastic Leukemia.2
187992152009Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization.2
191660982008ABL1 fusions in T-cell acute lymphoblastic leukemia.2
156744152005NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance.2
352533602022NUP214-ABL1 fusion in childhood T-ALL.1
350822692022Clinico-biological features of T-cell acute lymphoblastic leukemia with fusion proteins.1
315562192020Whole-exome sequencing reveals the subclonal expression of NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.1
198218272010Prognostic relevance of TLX3 (HOX11L2) expression in childhood T-cell acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing early and late re-intensification elements.1
162133632005ABL1 amplification in T-cell acute lymphoblastic leukemia.1
356502772022Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions.0
356412102022Chemotherapy Resistance in B-ALL with Cryptic NUP214-ABL1 Is Amenable to Kinase Inhibition and Immunotherapy.0
356440222022Prognostic utility of key copy number alterations in T cell acute lymphoblastic leukemia.0
347443392021Clinico-Hematological Profile and Copy Number Abnormalities in a Cohort of STIL-TAL1 and NUP214-ABL1 Positive Pediatric T-Cell Acute Lymphoblastic Leukemia.0
343071752021Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing.0
207264402010Identification and characterization of novel oncogenes in chronic eosinophilic leukemia and T-cell acute lymphoblastic leukemia.0

Bibliography

Pubmed IDLast YearTitleAuthors
168736732006NUP214-ABL1 in adult T-ALL: the GMALL study group experience.Burmeister T et al
189876552009Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia.Deenik W et al
228978472012Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.Roberts KG et al
243672742013Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.Atak ZK et al
274284282016Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.Liu YF et al
278240512016Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.Gu Z et al
286716872017Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.Seki M et al
286716882017The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.Liu Y et al

Summary

Fusion gene

NUP214/ABL1 NUP214 (9q34.13) ABL1 (9q34.12)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

NUP214/ABL1 (9q34)

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3445/nup214-abl1-(9q34)