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t(9;22)(p24;q11) BCR/JAK2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3456
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute myeloblastic leukemia without maturation (FAB type M1)|Chronic myeloproliferative disorder, NOS

Genes involved and Proteins

Gene NameBCR
Location 22q11.23
Gene NameJAK2
Location 9p24.1


A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11
Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A, Wörmann B, Haase D, Bohlander SK
2) translocation in a patient with a clinically typical chronic myeloid leukemia Genes Chromosomes Cancer
PMID 16001431
A BCR-JAK2 fusion gene from ins(22;9)(q11;p13p24) in a patient with atypical chronic myeloid leukemia
Xu Y, Yin J, Pan J, Wu C, Wang Q, Yao H, Wu D, Chen S, Sun A
Leuk Lymphoma 2013 Oct;54(10):2322-4
PMID 23432689
Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes
Schwaab J, Knut M, Haferlach C, Metzgeroth G, Horny HP, Chase A, Tapper W, Score J, Waghorn K, Naumann N, Jawhar M, Fabarius A, Hofmann WK, Cross NC, Reiter A
Ann Hematol 2015 Feb;94(2):233-8
PMID 25260694
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia
Cirmena G, Aliano S, Fugazza G, Bruzzone R, Garuti A, Bocciardi R, Bacigalupo A, Ravazzolo R, Ballestrero A, Sessarego M
Cancer Genet Cytogenet 2008 Jun;183(2):105-8
PMID 18503828
Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase
Cuesta-Domínguez Á, Ortega M, Ormazábal C, Santos-Roncero M, Galán-Díez M, Steegmann JL, Figuera Á, Arranz E, Vizmanos JL, Bueren JA, Río P, Fernández-Ruiz E
PLoS One 2012;7(2):e32451
PMID 22384256
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
Roberts KG, Morin RD, Zhang J, Hirst M, Zhao Y, Su X, Chen SC, Payne-Turner D, Churchman ML, Harvey RC, Chen X, Kasap C, Yan C, Becksfort J, Finney RP, Teachey DT, Maude SL, Tse K, Moore R, Jones S, Mungall K, Birol I, Edmonson MN, Hu Y, Buetow KE, Chen IM, Carroll WL, Wei L, Ma J, Kleppe M, Levine RL, Garcia-Manero G, Larsen E, Shah NP, Devidas M, Reaman G, Smith M, Paugh SW, Evans WE, Grupp SA, Jeha S, Pui CH, Gerhard DS, Downing JR, Willman CL, Loh M, Hunger SP, Marra MA, Mullighan CG
Cancer Cell 2012 Aug 14;22(2):153-66
PMID 22897847

Translocations implicated (Data extracted from papers in the Atlas)

 t(9;22)(p24;q11) BCR/JAK2

External links

BCR (22q11.23) JAK2 (9p24.1)

Mitelman databaset(9;22)(p24;q11) [Case List]    t(9;22)(p24;q11) [Transloc-MCList] BCR/JAK2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Tue Mar 12 13:14:35 CET 2019

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