t(10;12)(p12;q21) NAP1L1/MLLT10

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
NAP1L1
Location
12q21.2
Gene name
MLLT10
Location
10p12.31

Highly cited references

Pubmed IDYearTitleCitations
264555812016NAP1L1-MLLT10 is a rare recurrent translocation that is associated with HOXA activation and poor treatment response in T-cell acute lymphoblastic leukaemia.3

Bibliography

Pubmed IDLast YearTitleAuthors
222371062012The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.Zhang J et al
286716882017The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.Liu Y et al

Summary

Fusion gene

NAP1L1/MLLT10 NAP1L1 (12q21.2) MLLT10 (10p12.31)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

t(10;12)(p12;q21) NAP1L1/MLLT10

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2995/t(10;12)(p12;q21)-nap1l1-mllt10