t(14;14)(q11;q32) IGH/CEBPE

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
IGH
Location
14q32.33
Gene name
CEBPE
Location
14q11.2

Highly cited references

Pubmed IDYearTitleCitations
304872232018Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.75
299770162019Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism.10
270078922016The complex translocation (9;14;14) involving IGH and CEBPE genes suggests a new subgroup in B-lineage acute lymphoblastic leukemia.0

Bibliography

Pubmed IDLast YearTitleAuthors
171701242007Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Akasaka T et al
190274932008Translocation (14;14)(q11;q32) with simultaneous involvement of the IGH and CEBPE genes in B-lineage acute lymphoblastic leukemia.Han Y et al

Summary

Fusion gene

IGH/CEBPE IGH (14q32.33) CEBPE (14q11.2)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(14;14)(q11;q32) IGH/CEBPE

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2791/t(14;14)(q11;q32)-igh-cebpe