t(14;14)(q11;q32) TRA/TCL1A

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Nonneoplastic hematologic disorder/lesion

Genes Involved and Proteins

Gene name
Location
14q11.2
Gene name
Location
14q32.13

Highly cited references

Pubmed IDYearTitleCitations
269174882016Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.31
316771972020Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.6

Bibliography

Pubmed IDLast YearTitleAuthors
76629821995TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.Narducci MG et al

Summary

Fusion gene

TRA/TCL1A TRA (14q11.2) TCL1A (14q32.13)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(14;14)(q11;q32) TRA/TCL1A

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3282/t(14;14)(q11;q32)-tra-tcl1a