Atlas of Genetics and Cytogenetics in Oncology and Haematology

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inv(14)(q11q32)|t(14;14)(q11;q32) IGH/TRA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3487
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Angioimmunoblastic T-cell lymphoma|Mature T- and NK-cell neoplasm, NOS|T-prolymphocytic leukemia

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameTRA
Location 14q11.2


Immunoglobulin VH-T cell receptor C alpha fusion mRNA resulting from chromosome inversion include the T cell-associated 5' exon ET
Fisch P, Foroni L, Forster A, Lavenir I, Mengle-Gaw L, Rabbitts TH
Eur J Immunol 1992 Oct;22(10):2745-8
PMID 1339353
Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas
Leich E, Haralambieva E, Zettl A, Chott A, Rüdiger T, Höller S, Müller-Hermelink HK, Ott G, Rosenwald A
J Pathol 2007 Sep;213(1):99-105
PMID 17582237
A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci
Denny CT, Yoshikai Y, Mak TW, Smith SD, Hollis GF, Kirsch IR
Nature 1986 Apr 10-16;320(6062):549-51
PMID 3008004
Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development
Denny CT, Hollis GF, Hecht F, Morgan R, Link MP, Smith SD, Kirsch IR
Science 1986 Oct 10;234(4773):197-200
PMID 3092355
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors
Baer R, Chen KC, Smith SD, Rabbitts TH
Cell 1985 Dec;43(3 Pt 2):705-13
PMID 3935328
Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia
Davey MP, Bertness V, Nakahara K, Johnson JP, McBride OW, Waldmann TA, Kirsch IR
Proc Natl Acad Sci U S A 1988 Dec;85(23):9287-91
PMID 3194425

Translocations implicated (Data extracted from papers in the Atlas)

 inv(14)(q11q32)|t(14;14)(q11;q32) IGH/TRA

External links

IGH (14q32.33) TRA (14q11.2)

Mitelman databaseinv(14)(q11q32)|t(14;14)(q11;q32) [Case List]    inv(14)(q11q32)|t(14;14)(q11;q32) [Transloc-MCList] IGH/TRA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Feb 19 18:23:28 CET 2020

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