| Written | 2018-01 | Jean-Loup Huret, Philippe Dessen |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 3182 |
| Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute |
| Clinics and Pathology |
| Disease | Chronic myelomonocytic leukemia |
| Genes involved and Proteins |
| Gene Name | RUNX1 |
| Location | 21q22.12 |
| Gene Name | UBL7 |
| Location | 15q24.1 |
| Bibliography |
| t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders |
| L'Abbate A, Tolomeo D, De Astis F, Lonoce A, Lo Cunsolo C, Mühlematter D, Schoumans J, Vandenberghe P, Van Hoof A, Palumbo O, Carella M, Mazza T, Storlazzi CT |
| Mol Cancer 2015 Dec 16;14:211 |
| PMID 26671595 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(15;21)(q24;q22) RUNX1/UBL7 | |
| External links |
| Mitelman database | t(15;21)(q24;q22) |
| COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
| arrayMap (UZH-SIB Zurich) | [select an item] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sun Jul 12 19:49:00 CEST 2020 |
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