t(X;14)(q28;q11) TRA/MTCP1

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Nonneoplastic hematologic disorder/lesion|T-prolymphocytic leukemia

Genes Involved and Proteins

Gene name
TRA
Location
14q11.2
Gene name
MTCP1
Location
Xq28

Highly cited references

Pubmed IDYearTitleCitations
269174882016Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.31

Bibliography

Pubmed IDLast YearTitleAuthors
81522521994A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia.Thick J et al
83617601993MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations.Stern MH et al

Summary

Fusion gene

TRA/MTCP1 TRA (14q11.2) MTCP1 (Xq28)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

t(X;14)(q28;q11) TRA/MTCP1

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/3278/t(x;14)(q28;q11)-tra-mtcp1