t(1;3)(p36;p21)
2002-05-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
found in various hematological malignancies: 2 chronic myelogenous leukemia (CML), 1 of which in accelerated phase, 1 myelodysplastic syndrome (MDS) of RAEB type, 2 treatment related MDS, 2 M3- AML (acute myeloid leukemia), 2 acute lymphocytic leukemias (ALL), and 1 treatment related ALL, 3 non Hodgkin lymphoma (NHL), (2 follicular and 1 diffuse large cell NHL) . Five patients had a history of a previous treatment for malignancy (alkylating agent in 3 cases).
Epidemiology
only 13 cases to date; 7 to 87 yr old patients, most patients being in the fifties; sex ratio: 7M/6F
Prognosis
very variable survival, from 25 days to 16 yrs+
Note
according to the variability in the above data, the t(1;3)(p36;p21) is likely to be heterogeneous also at the molecular level.
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11850073 | 2002 | Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization. | Dave BJ et al |
| 11241790 | 2001 | Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18). | Horsman DE et al |
| 2310831 | 1990 | Cytogenetic analysis of chimerism and leukemia relapse in chronic myelogenous leukemia patients after T cell-depleted bone marrow transplantation. | Offit K et al |
| 11979552 | 2002 | t(1;3)(p36;p21) is a recurring therapy-related translocation. | Sato Y et al |
| 8976389 | 1996 | 3p21 is a recurrent treatment-related breakpoint in myelodysplastic syndrome and acute myeloid leukemia. | Shi G et al |
| 7803794 | 1995 | Sequential analysis of 43 patients with non-Hodgkin's lymphoma: clinical correlations with cytogenetic, histologic, immunophenotyping, and molecular studies. | Whang-Peng J et al |
Summary
Class disease
NHL
Citation
Jean-Loup Huret
t(1;3)(p36;p21)
Atlas Genet Cytogenet Oncol Haematol. 2002-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1237/t(1;3)(p36;p21)
