| Written | 1999-11 | Antonio Cuneo |
| Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
| ICD-Morpho | 9920/3 Therapy-related myeloid neoplasms |
| Atlas_Id | 1157 |
 | |
| partial karyotype (G-banding) showing the t(1;7)(p36;q34) | |
| Clinics and Pathology |
| Disease | acute myeloid leukemia (AML), presenting as a de novo condition or after preceeding myelodysplastic syndrome or exposure to myelotoxic agents |
| Phenotype / cell stem origin | M2/M4 by FAB criteria, frequently with trilineage myelodysplasia: positivity for myeloid markers (i.e. CD13, CD33) as well as for CD117, CD34 and TdT; lymphoid-associated markers tested negative in the reported cases |
| Epidemiology | the frequency of this anomaly in AML is < 1% |
| Prognosis | the cells may be susceptible to chemotherapy since all reported cases achieved complete remission, despite the presence of other unfavourable prognostic factors |
| Cytogenetics |
| Note | this translocation may be related to a 1p;7q translocation described in myelodysplastic syndrome, whereas it must be distinguished from the T-ALL associated t(1;7)(p32;q34), involving the TCR gene and a more proximal breakpoint on 7q |
| Cytogenetics Morphological | the translocation is easy to visualize in G-banded preparations because the dark 7q35 band moves on top of the derivative 1p |
| Additional anomalies | associated / additional anomalies may include +8 and the classical t(6;9)(p23;q34) |
| Genes involved and Proteins |
| Note | the involved genes are unknown |
| Bibliography |
| The role of chromosome translocations in T cell acute leukemia. |
| Hwang LY, Baer RJ |
| Current opinion in immunology. 1995 ; 7 (5) : 659-664. |
| PMID 8573309 |
| A novel translocation t(1;7)(p36;q34) in three patients with acute myeloid leukaemia. |
| Specchia G, Cuneo A, Liso V, Contino R, Pastore D, Gentile E, Rocchi M, Castoldi GL |
| British journal of haematology. 1999 ; 105 (1) : 208-214. |
| PMID 10233385 |
| t(1;7)(p36;q32): a new recurring abnormality in primary myelodysplastic syndrome. |
| Stefanescu DT, Colita D, Nicoara S, Calin G |
| Cancer genetics and cytogenetics. 1994 ; 75 (2) : 103-105. |
| PMID 8055471 |
| Citation |
| This paper should be referenced as such : |
| Cuneo, A |
| t(1;7)(p36;q34) |
| Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):195-195. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0107ID1157.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(1;7)(p36;q34) | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:25:13 CET 2020 |
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