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Written1999-11Antonio Cuneo
Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy

(Note : for Links provided by Atlas : click)


ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1157
  partial karyotype (G-banding) showing the t(1;7)(p36;q34)

Clinics and Pathology

Disease acute myeloid leukemia (AML), presenting as a de novo condition or after preceeding myelodysplastic syndrome or exposure to myelotoxic agents
Phenotype / cell stem origin M2/M4 by FAB criteria, frequently with trilineage myelodysplasia: positivity for myeloid markers (i.e. CD13, CD33) as well as for CD117, CD34 and TdT; lymphoid-associated markers tested negative in the reported cases
Epidemiology the frequency of this anomaly in AML is < 1%
Prognosis the cells may be susceptible to chemotherapy since all reported cases achieved complete remission, despite the presence of other unfavourable prognostic factors


Note this translocation may be related to a 1p;7q translocation described in myelodysplastic syndrome, whereas it must be distinguished from the T-ALL associated t(1;7)(p32;q34), involving the TCR gene and a more proximal breakpoint on 7q
Cytogenetics Morphological the translocation is easy to visualize in G-banded preparations because the dark 7q35 band moves on top of the derivative 1p
Additional anomalies associated / additional anomalies may include +8 and the classical t(6;9)(p23;q34)

Genes involved and Proteins

Note the involved genes are unknown


The role of chromosome translocations in T cell acute leukemia.
Hwang LY, Baer RJ
Current opinion in immunology. 1995 ; 7 (5) : 659-664.
PMID 8573309
A novel translocation t(1;7)(p36;q34) in three patients with acute myeloid leukaemia.
Specchia G, Cuneo A, Liso V, Contino R, Pastore D, Gentile E, Rocchi M, Castoldi GL
British journal of haematology. 1999 ; 105 (1) : 208-214.
PMID 10233385
t(1;7)(p36;q32): a new recurring abnormality in primary myelodysplastic syndrome.
Stefanescu DT, Colita D, Nicoara S, Calin G
Cancer genetics and cytogenetics. 1994 ; 75 (2) : 103-105.
PMID 8055471


This paper should be referenced as such :
Cuneo, A
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):195-195.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(1;7)(p36;q34)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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