| Clinics and Pathology |
| Disease | Acute non lymphocytic leukemia (ANLL), M2-ANLL type; this leukemia case is likely to be treatment related (see below) |
| Epidemiology | only 1 case to date, a 55yr old male patient who has had a non Hodgkin lymphoma (NHL) with t(14;18)(q32;q21) 3 yrs before onset of the ANLL. |
| Evolution | Complete remission of the ANLL was achieved, but the NHL relapsed and an advanced gastric carcinoma was found and the patient died shortly afterwards. |
| Genes involved and Proteins |
| Note | This translocation appears to be closely related to other translocations involving NUP98 and an homeodomain bearing protein, i.e. the t(2;11)(q31;p15),.with HOXD13 or with HOXD11 involvement, the t(7;11)(p15;p15),.with HOXA9 or with HOXA13 involvement, the t(9;11)(q34;p15), with PRRX2 involvement, and the t(11;12)(p15;q13) ID: nĦidentif> with HOXC11 or with |
| Gene Name | PRRX1 |
| Location | 1q23 |
| Protein | Protein with a homeodomain |
| Gene Name | NUP98 |
| Location | 11p15.4 |
| Protein | nucleoporin 98, a 98 kDa component of the nuclear pore complex implicated in nucleo-cytoplasmic transport |
| Result of the chromosomal anomaly |
| Description | In frame fusion of NUP98 to PRRX1 exon 2; no reciprocal fusion transcript |
| Description | The chimeric protein contains the N-term half of NUP98, including the docking site to the homeodomain of PRRX1. |
| Oncogenesis | The PRRX1 homeodomain may be upregulated |
| External links |
| Other database | t(1;11)(q23;p15) | Mitelman database (CGAP - NCBI) | |
| Other database | t(1;11)(q23;p15) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). |
| Nakamura T, Yamazaki Y, Hatano Y, Miura I |
| Blood. 1999 ; 94 (2) : 741-747. |
| PMID 10397741 |
| Translocation (1;11)(q23;p15), a novel simple variant of translocation (7;11)(p15;p15), in a patient with AML (M2) accompanied by non-Hodgkin lymphoma and gastric cancer. |
| Hatano Y, Miura I, Kume M, Miura AB |
| Cancer genetics and cytogenetics. 2000 ; 117 (1) : 19-23. |
| PMID 10700860 |
| Contributor(s) |
| Written | 09-2005 | Jean Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(1;11)(q23;p15). Atlas Genet Cytogenet Oncol Haematol. Septem
ber 2005 . URL : http://AtlasGeneticsOncology.org/Genes/t0111q23p15ID1169.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:06:13 2008 |
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