| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML) and treatment related acute myeloid leukaemia (t-AML) |
| Epidemiology | Only 2 cases to date, a 41 year old female patient with M1 AML, and a 70 year old male patient with t-AML |
| Prognosis | No data |
| Cytogenetics |
| Cytogenetics Morphological | sole anomaly in the t-AML case, accompanied with del(7q) and a complex karyotype in the other case. |
| Genes involved and Proteins |
| Note | The partner of EVI1 is yet unknown. |
| Gene Name | EVI1 |
| Location | 3q26.2 |
| Protein | Transcrition factor; EVI1 targets include:GATA2, ZBTB16 /PLZF, ZFPM2/FOG2, JNK and the PI3K/AKT pathway. Role in cell cycle progression, likely to be cell-type dependant; antiapoptotic factor; involved in neuronal development organogenesis; role in hematopoietic differsntiation |
| External links |
| Other database | t(3;6)(q25;q26) | Mitelman database (CGAP - NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. |
| Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F |
| Genes, chromosomes & cancer. 2002 ; 33 (1) : 60-72. |
| PMID 11746988 |
| EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements. |
| Poppe B, Dastugue N, Vandesompele J, Cauwelier B, De Smet B, Yigit N, De Paepe A, Cervera J, Recher C, De Mas V, Hagemeijer A, Speleman F |
| Genes, chromosomes & cancer. 2006 ; 45 (4) : 349-356. |
| PMID 16342172 |
| The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions. |
| Wieser R |
| Gene. 2007 ; 396 (2) : 346-357. |
| PMID 17507183 |
| Contributor(s) |
| Written | 05-2007 | Jean-Loup Huret |
| Jean Loup HURET, Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;6)(q25;q26). Atlas Genet Cytogenet Oncol Haematol. May 2007 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0306q25q26ID1211.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/38479/1/05-2007-t0306q25q26ID1211.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:36:58 CET 2013 |
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