BCL6 (B-Cell Lymphoma 6)

3q27.3

706 amino acids; composed of a NH2-term BTB/POZ domain (amino acids 1-130 (32-99 according to Swiss-Prot) which mediates homodimerization and protein-protein interactions with other corepressors (including HDAC1 and NCOR2/SMRT to constitute a large repressing complex, another transcription repression domain (191-386), PEST sequences (300-417) with a KKYK motif (375-379), and six zinc finger at the C-term (518-541, 546-568, 574-596, 602-624, 630-652, 658-681), responsible for sequence specific DNA binding. Transcription repressor; recognizes the consensus sequence: TTCCT(A/C)GAA (Albagli-Curiel, 2003). Role in germinal centers of lymphoid follicles. BCL6 prevents ATM and TP53 to induce apoptosis in response to DNA rearrangements such as somatic hypermutation and class switch recombination. Therefore essential for normal B cell development.

SNHG5 (small nucleolar RNA host gene 5)

6q14.3

SNHG5 is also known as U50HG. SNHG5 exons do not encode a polypeptide product (small nucleolar RNA (snoRNA) sequence). SNHG5 is composed of six exons. It possesses an oligopyrimidine tract that is characteristic of the 5-terminal oligopyrimidine (5TOP gene family) which have been shown to regulate cell growth.