Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(3;12)(q26;p13)
| Identity |
 | |
| t(3;12)(q26;p13) G- banding - Courtesy Jean-Luc Lai and Alain Vanderhaegen | |
| Clinics and Pathology |
| Disease | myeloid lineage: MDS in transformation, ANLL, BC-CML |
| Phenotype / cell stem origin | multilineage involvement; RAEB --> M2, M7 and others ANLL subtypes |
| Epidemiology | only 8 cases described so far; sex ratio: 3M/1F; age: 3-87 yrs (med: 40 yrs) |
| Cytology | megakaryocytes dysplasia |
| Prognosis | very poor; survival =BE 1yr |
| Cytogenetics |
| Cytogenetics Molecular | heterogenous breakpoints PROBES EVI1: ly2 and l3 E Parganas, St Jude Children's Reseach Hospital, MeMphis,TN; MDS1: P856 G Nucifora, University of Chicago, IL; TEL: YAC 958b8 CEPHII Mega-YAC library Paris, France; TEL: cDNA c50F4, c163E7, c148B6 Lawrence Livermore National Laboratories, Livermore, CA |
| Additional anomalies | del(7q) or -7 |
| Genes involved and Proteins |
| Gene Name | MDS1 |
| Gene Name | EVI1 |
| Location | 3q26 |
| Gene Name | ETV6 |
| Location | 12p13 |
| External links |
| Other database | t(3;12)(q26;p13) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;12)(q26;p13) | CancerChromosomes (NCBI) |
| Bibliography |
| Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. |
| Golub TR, Barker GF, Lovett M, Gilliland DG |
| Cell. 1994 ; 77 (2) : 307-316. |
| PMID 8168137 |
| Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes. |
| Raynaud SD, Baens M, Grosgeorge J, Rodgers K, Reid CD, Dainton M, Dyer M, Fuzibet JG, Gratecos N, Taillan B, Ayraud N, Marynen P |
| Blood. 1996 ; 88 (2) : 682-689. |
| PMID 8695816 |
| Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study. |
| Secker-Walker LM, Mehta A, Bain B |
| British journal of haematology. 1995 ; 91 (2) : 490-501. |
| PMID 8547101 |
| Contributor(s) |
| Written | 09-1997 | François Desangles |
| Citation |
| This paper should be referenced as such : |
| Desangles F . t(3;12)(q26;p13). Atlas Genet Cytogenet Oncol Haematol. Septem
ber 1997 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0312.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 6 15:45:42 CET 2010 |
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