| Clinics and Pathology |
| Disease | Extra-nodal Marginal Zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type, also called MALT lymphoma |
| Note | MALT lymphomas without the t(3;14) are frequently associated with either a t(1;14)(p22;q32) ( BCL10 / IGH), a t(11;18)(q21;q21) ( API2 / MALT1, or a t(14;18)(q32;q21) (IGH/MALT1) |
| Epidemiology | 9 cases detected to date |
| Clinics | MALT lymphoma is an indolent disease involving most often the stomach, the lung, the thyroid, the salivary gland, the orbit, and the skin, with a non random anatomic distribution according to the translocation. The t(3;14) is frequently found in MALT lymphomas of the thyroid, the orbit, and the skin. |
| Cytogenetics |
| Additional anomalies | +3 is found in half cases |
| Genes involved and Proteins |
| Gene Name | FOXP1 |
| Location | 3p14.1 |
| Protein | Transcription factor; member of the FOXP subfamily, characterized by a DNA binding forkhead. |
| Gene Name | IGH |
| Location | 14q32 |
| Result of the chromosomal anomaly |
| Description | Breakpoint upstream the first 5' non coding exon of FOXP1 |
| External links |
| Other database | t(3;14)(p14;q32) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;14)(p14;q32) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. |
| Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (4) : 652-658. |
| PMID 15703784 |
| Contributor(s) |
| Written | 07-2005 | Jean Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;14)(p14;q32). Atlas Genet Cytogenet Oncol Haematol. July 2005 . URL : http://AtlasGeneticsOncology.org/Genes/t0314p14q32ID1398.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:06:35 2008 |
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