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t(6;14)(q25-27;q32) BCL11B/?

Written2008-07Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1324

Clinics and Pathology

Disease Haematological malignancies
Phenotype / cell stem origin The phenotype is variable, and the translocation may be heterogenous at the level of the genes involved; there was one acute lymphoblastic leukaemia (ALL), four biphenotypic acute leukaemias (BAL), two of which with expression of myeloid and T-cell markers, one acute myeloid leukaemia (AML), one chronic T-cell neoplasm, and one chronic lymphocytic leukaemia (B-CLL) Binet stage B.
Epidemiology Only 8 cases to date (5M/2F); there was 3 children and 4 adults (ages were: 12, 14, 28, 41, 54, 62, ?, ?).
Prognosis Survival data is available in only 5 cases; patients died: "shortly", at 17 months, 33 mths, 45 mths, and 112 mths after diagnosis.

Cytogenetics

Additional anomalies The t(6;14) was the sole anomaly in five of eight cases; there was del(13q) in two cases, +12 in one, +21 in one.

Genes involved and Proteins

Note In only one of the above mentioned cases, BCL11B was detected as being involved in the translocation; the partner is unknown (Bezrookove et al., 2004). The case with BCL11B involvement was a case of M1-AML in a 54 year old male patient who died shortly after diagnosis. The t(6;14) was the sole anomaly. In other cases, data is missing concerning the genes implicated in the translocation.
Gene NameBCL11B (B-cell lymphoma/leukaemia 11B)
Location 14q32.2
Protein Kruppel-like zinc finger protein. Expressed in the immune system and in the brain. Regulates thymic differentiation and survival.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.
Case Report An adult case of biphenotypic acute leukemia with t(6;14)(q25;q32)

Bibliography

Is t(6;14) a non-random translocation in childhood acute mixed lineage leukemia?
Batanian JR, Dunphy CH, Gale G, Havlioglu N.
Cancer Genet Cytogenet. 1996 Aug;90(1):29-32.
PMID 8780743
 
A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.
Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstock GC, Rosenberg C.
Cancer Genet Cytogenet. 2004 Feb;149(1):72-6.
PMID 15104287
 
Acute mixed lineage leukemia and a t(6;14)(q25;q32) in two adults.
Georgy M, Yonescu R, Griffin CA, Batista DA.
Cancer Genet Cytogenet. 2008 Aug;185(1):28-31.
PMID 18656690
 
14q32 translocations are associated with mixed-lineage expression in childhood acute leukemia.
Hayashi Y, Pui CH, Behm FG, Fuchs AH, Raimondi SC, Kitchingman GR, Mirro J Jr, Williams DL.
Blood. 1990 Jul 1;76(1):150-6.
PMID 2364166
 
Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia.
Heerema NA, Sather HN, Sensel MG, La MK, Hutchinson RJ, Nachman JB, Reaman GH, Lange BJ, Steinherz PG, Bostrom BC, Gaynon PS, Uckun FM.
Cancer. 2002 Feb 15;94(4):1102-10.
PMID 11920481
 
Cytogenetic findings in 21 cases of peripheral T-cell lymphoma.
Inwards DJ, Habermann TM, Banks PM, Colgan JP, Dewald GW.
Am J Hematol. 1990 Oct;35(2):88-95.
PMID 2399910
 
Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.
Mayr C, Speicher MR, Kofler DM, Buhmann R, Strehl J, Busch R, Hallek M, Wendtner CM.
Blood. 2006 Jan 15;107(2):742-51. Epub 2005 Sep 22.
PMID 16179374
 
Cytogenetics of childhood acute nonlymphocytic leukemia.
Raimondi SC, Kalwinsky DK, Hayashi Y, Behm FG, Mirro J Jr, Williams DL.
Cancer Genet Cytogenet. 1989 Jul 1;40(1):13-27.
PMID 2758395
 

Citation

This paper should be referenced as such :
Huret, JL
t(6;14)(q25-27;q32)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(7):515-516.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0614q25q32ID1324.html

Translocations implicated (Data extracted from papers in the Atlas)

 t(6;14)(q25;q32) BCL11B/?

External links

Mitelman databaset(6;14)(q25;q32) [Case List]    t(6;14)(q25;q32) [Transloc-MCList] BCL11B/? [Fusion-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
REVIEW articlesautomatic search in PubMed
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