t(7;14)(q21;q13)
2008-02-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Myeloproliferative syndrome (MPD) and acute myeloid leukaemia (AML)
Phenotype stem cell origin
One case was a M2-AML, another case was a MPD associated with an AML, the third case was an AML not otherwise specified.
Epidemiology
Only three cases available; two male and one female patients aged 62, 63, and 71 yrs.
Cytogenetics
Cytogenetics morphological
The 3 cases were found using multi-FISH techniques; this translocation may therefore be partially cryptic, especially so as it is found in complex karyotypes.
Additional anomalies
The three cases present with very similar cytogenetic profiles: major karyotypic anomalies were present in 3 out of 3 cases; -5/del(5q) was found in the three cases, and +8 and -14 were found in two cases each.
Genes Involved and Proteins
Note
Genes involved are unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10865969 | 2000 | Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome. | Mohr B et al |
| 11746988 | 2002 | Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. | Van Limbergen H et al |
| 9090389 | 1997 | Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. | Veldman T et al |
Citation
Jean-Loup Huret
t(7;14)(q21;q13)
Atlas Genet Cytogenet Oncol Haematol. 2008-02-01
Online version: http://atlasgeneticsoncology.org/haematological/1484/t(7;14)(q21;q13)
