t(7;17)(q32-34;q23) MSI2/?

2005-08-01   Jean-Loup Huret  

1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Chronic myelogenous leukemia (CML) in accelerated phase (AP-CML)

Epidemiology

only one case to date, a female patient, aged a 40 at the time of the AP-CML

Prognosis

Chronic phase of CML lasted 2 yrs before progression into an accelerated phase accompanied with the appearance of the t(7;17); 2 mths later, a blast crisis occurred, and the patient died 9 mths after the AP-CML, 33 mths after initial diagnosis of CML.

Cytogenetics

Cytogenetics morphological

at(9;22)(q34;q11) was, indeed, present

Cytogenetics molecular

Cryptic translocation; recognized by multicolor FISH plus locus-specific FISH

Genes Involved and Proteins

Note
The gene involved on chromosome 7 is undefined, due to a lack of material for further analysis, but it seems to be a gene of the plexin family, with, perhaps, a sema domain, a plexin repeat, and an immunoglobulin-like plexin transcription factor domain
Gene name
MSI2 (musashi homolog 2 (drosophila))
Location
17q22
Dna rna description
at least 15 exons; various splicing.
Protein description
possesses 2 RNA recognition motifs; likely to be a RNA binding protein; may play a role in RNA metabolism in the cytoplasm; The mouse homolog is ubiquitous, and particularly active in the brain development.

Highly cited references

Pubmed IDYearTitleCitations
237761462013Specificity factors in cytoplasmic polyadenylation.312
324084942020RNA-Binding Proteins in Acute Leukemias.255
281438722017Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.114
387556312024DNA methylation and type 2 diabetes: a systematic review.105
337628292021Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT.102
378020552023Single-cell mapping identifies MSI(+) cells as a common origin for diverse subtypes of pancreatic cancer.88
387608412024Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models.81
256648532015Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.76
354268122022[Advances in research of Musashi2 in solid tumors].72
380410162023Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation.69
383476002024Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.67
316035832020Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.65
287184122017Stem Cells, Cancer, and MUSASHI in Blood and Guts.64
361678292022TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.63
386598282024Musashi-2 (MSI2) regulation of DNA damage response in lung cancer.63
340474772021Glioma glycolipid metabolism: MSI2-SNORD12B-FIP1L1-ZBTB4 feedback loop as a potential treatment target.61
335049422021Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target.59
383737972024The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation.55
365098912023Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.54
379410422023Musashi-2 in cancer-associated fibroblasts promotes non-small cell lung cancer metastasis through paracrine IL-6-driven epithelial-mesenchymal transition.54
395223212025A novel regulatory axis of MSI2-AGO2/miR-30a-3p-CGRRF1 drives cancer chemoresistance by upregulating the KRAS/ERK pathway.54
318336122020RNA-binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression.54
351022502022RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7.52
365309892022Prognostic value of Musashi 2 (MSI2) in cancer patients: A systematic review and meta-analysis.51
388816742024CircMALAT1 promotes cancer stem-like properties and chemoresistance via regulating Musashi-2/c-Myc axis in esophageal squamous cell carcinoma.51
257748282015Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.51
345892842021Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression.51
348778142022Msi2-mediated MiR7a-1 processing repression promotes myogenesis.50
377979212024Msi2 enhances muscle dysfunction in a myotonic dystrophy type 1 mouse model.50
371496612023MicroRNA-143 acts as a tumor suppressor through Musashi-2/DLL1/Notch1 and Musashi-2/Snail1/MMPs axes in acute myeloid leukemia.48
301268422018Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.48
350734592022LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability.47
367134282022MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota.47
337232472021Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).47
331686292021The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.47
370348132023Regulation of VEGFR2 and AKT signaling by Musashi-2 in lung cancer.47
318886852019Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway.46
319525412020Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.46
371739952023Regulation of VEGFR2 and AKT Signaling by Musashi-2 in Lung Cancer.42
390977352024MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progression.41
274494992017The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer.41
324482692020RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.41
343223862021Downregulation of SOX2-OT Prevents Hepatocellular Carcinoma Progression Through miR-143-3p/MSI2.40
353012802022The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling.39
285144432017Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia.37
341459292021MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma.37
386456642024Mechanism of Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair.36
365960172022Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.36
296419912018PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells.36
351537522021Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer.35
300342432018MSI2 knockdown represses extrahepatic cholangiocarcinoma growth and invasion by inhibiting epithelial-mesenchymal transition.35
270344662016Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration.35
335532412020RNA-Binding Protein MSI2 Binds to miR-301a-3p and Facilitates Its Distribution in Mitochondria of Endothelial Cells.35
342370572021Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression.34
382347202023Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia.33
263085312015Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin.33
260459882015Musashi-2 promotes hepatitis Bvirus related hepatocellular carcinoma progression via the Wnt/β-catenin pathway.31
327798762020Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.30
268988842016MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.27
371171912023MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells.27
308540352019Increased musashi 2 expression indicates a poor prognosis and promotes malignant phenotypes in gastric cancer.27
338419302021Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC).24
365999322023ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.23
295562942018Musashi-2 is a prognostic marker for the survival of patients with cervical cancer.22
224968682012Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells.19
336092832021Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.0
379237882023Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.0
378017082024Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.0
215771042011Roles for MSI2 and PROX1 in hematopoietic stem cell activity.0
382709442024Darwin, MSI2, and relapse in T-ALL.0
225175882012Musashi 2 in hematopoiesis.0
376065812023Lack of Musashi-2 induces type IIa fiber-dominated muscle atrophy.0
373982832023Musashi-2 (MSI2) regulation of DNA damage response in lung cancer.0
208038132010Leukaemia: Comfortably MSI2-NUMB.0
240763742014Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway.0
312501542019MSI2-TGF-β/TGF-β R1/SMAD3 positive feedback regulation in glioblastoma.0
337802632021LncRNA TUG1 promotes Ewing's sarcoma cell proliferation, migration, and invasion via the miR-199a-3p-MSI2 signaling pathway.0
380599152023MSI2 Modulates Unsaturated Fatty Acid Metabolism by Binding FASN in Bovine Mammary Epithelial Cells.0
275939292017Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.0
378436252023Musashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation.0
273229532016Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway.0
250909282015Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia.0
253634002015Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.0
345814572021MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways.0
276002582016Musashi-2 is a novel regulator of paclitaxel sensitivity in ovarian cancer cells.0
266392452016Prognostic significance of the Musashi-2 (MSI2) gene in childhood acute lymphoblastic leukemia.0
227847122012Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients.0
331314122022Unravelling the drugability of MSI2 RNA recognition motif (RRM) protein and the prediction of their effective antileukemia inhibitors from traditional herb concoctions.0
394385892025MSI2 mediates WNT/β-Catenin pathway function in hematopoietic stem cells.0
327801972020RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.0
246718792014Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.0
376334782023Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.0
376065662023Exploring the role of m6A methylation regulators in glioblastoma multiforme and their impact on the tumor immune microenvironment.0
399690912025ELK4 transcription promotes MSI2-mediated progression of non-small cell lung cancer through the TGF-β/SMAD3 pathway.0
316921352020Interplay between the RNA binding-protein Musashi and developmental signaling pathways.0
398620692025Update on the Progress of Musashi-2 in Malignant Tumors.0
217531872011MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia.0
277210182017Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation.0
290544892017Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways.0
343098752021Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
156805822005Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences.Akindahunsi AA et al
126491772003A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).Barbouti A et al
124071782002RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.Sakakibara S et al

Citation

Jean-Loup Huret

t(7;17)(q32-34;q23) MSI2/?

Atlas Genet Cytogenet Oncol Haematol. 2005-08-01

Online version: http://atlasgeneticsoncology.org/haematological/1402/t(7;17)(q32-34;q23)-msi2