Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(9;11)(q34;q23) FBP17/MLL
| Identity |
| Other names | ins(11;9)(q23;q34)inv(11)(q13;q23) |
| Clinics and Pathology |
| Disease | acute non lymphocytic leukemia (ANLL) |
| Phenotype / cell stem origin | one case of M4-ANLL |
| Epidemiology | unknown |
| Clinics | WBC 35 X 109/l |
| Prognosis | poor |
| Cytogenetics |
| Cytogenetics Molecular | YAC 13HH4; P1 ICRFP700L11103Q5 |
| Genes involved and Proteins |
| Gene Name | FBP17 |
| Location | 9q34 |
| Dna / Rna | at least 2042 bp |
| Protein | at least 679 amino acids |
| Gene Name | MLL |
| Location | 11q23 |
| Dna / Rna | 11910 bp |
| Protein | 3970 amino acids; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Result of the chromosomal anomaly |
| Description | 5'-MLL/FBP17-3' |
 | |
| Description | Hybrid transcript MLL/FBP17 contains the following domains: from MLL: AT-hook, DNA-Methyltransferase, Zinc-Fingers; from FBP17:cdc15 homology region, putative rho-binding domain, SH3-domain |
| Expression Localisation | nuclear |
| Oncogenesis | unknown |
| External links |
| Other database | t(9;11)(q34;q23) FBP17/MLL | Mitelman database (CGAP - NCBI) | |
| Other database | t(9;11)(q34;q23) FBP17/MLL | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. |
| Fuchs U, Rehkamp G, Haas OA, Slany R, K‰çnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8756-8761. |
| PMID 11438682 |
| Contributor(s) |
| Written | 06-2001 | Uta Fuchs, Arndt Borkhardt |
| Citation |
| This paper should be referenced as such : |
| Fuchs U, Borkhardt A . t(9;11)(q34;q23) FBP17/MLL. Atlas Genet Cytogenet Oncol Haematol. June 2001 . URL : http://AtlasGeneticsOncology.org/Genes/t0911FBPID1205.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:07:07 2008 |
For comments and suggestions or contributions, please contact us