t(9;11)(q34;p15) NUP98/PRRX2
2005-01-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myelomonocytic leukemia (M4 AML)
Etiology
This leukemia case is likely to be treatment related (a lymphoma was treated 4 years previously).
Epidemiology
Only one case to date: a 65-year-old female patient.
Prognosis
No data.
Genes Involved and Proteins
Gene name
PRRX2 (paired related homeobox 2)
Location
9q34.11
Protein description
Class II homeobox gene.
Gene name
NUP98 (nucleoporin 98 kDa)
Location
11p15.4
Protein description
Nucleoporin 98, a 98 kDa component of the nuclear pore complex implicated in nucleo-cytoplasmic transport.
Result of the Chromosomal Anomaly
Description
5--> exon 11 of NUP98 is fused in frame with PRRX2 exon 2 to 3.
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31728617 | 2019 | Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15496970 | 2005 | A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. | Gervais C et al |
Summary
Fusion gene
NUP98/PRRX2 NUP98 (11p15.4) PRRX2 (9q34.11) M t(9;11)(q34;p15)|NUP98/PRRX2 NUP98 (11p15.4) PRRX2 (9q34.11) TIC
Citation
Jean-Loup Huret
t(9;11)(q34;p15) NUP98/PRRX2
Atlas Genet Cytogenet Oncol Haematol. 2005-01-01
Online version: http://atlasgeneticsoncology.org/haematological/1380/t(9;11)(q34;p15)-nup98-prrx2
