Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(10;11)(p11.2;q23)
| Identity |
| Note | must not be confused with the t(10;11)(p12;q23) involving AF10 in 10p12 and MLL, or the t(10;11)(p13;q14-21), also involving AF10, but with CALM on chromosome 11 |
| Clinics and Pathology |
| Disease | acute non lymphoblastic leukemia (ANLL) |
| Phenotype / cell stem origin | M4/M5 |
| Epidemiology | Only three cases reported to date: all infants (2M/1F). |
| Clinics | Two boys aged 2 and 8 months respectively, achieved complete remission (1 yrs+, 5 yrs+), the newborn girl died soon for infection during induction. |
| Cytogenetics |
 | |
| A. Partial Q-banded karyotype showing the t(10;11)(p11.2;q23), derivative chromosomes are on the right. B. FISH using RP13-31H8 (ABI1) shows one signal on the normal chromosome 10 and the another one split between the p arm of der(10) (arrowheads) and the q arm of der(11) (arrow). The BAC clone was provided by Prof. M.Rocchi. | |
| Genes involved and Proteins |
| Gene Name | ABI-1 |
| Location | 10p11.2 |
| Dna / Rna | different splicings |
| Protein | possesses a SH3 domain; cell growth inhibitor |
| Gene Name | MLL |
| Location | in 11q23 |
| Dna / Rna | 13-15 kb mRNA |
| Protein | 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Result of the chromosomal anomaly |
| Description | 5' MLL-3' ABI1; fusion at MLL exon 6-7. The breakpoint of ABI1 gene is the same in the two cases studied (nucleotide 433), while the breakpoint of MLL can be located either in exon 6 or 7. |
| Description | 1727 amino acids (1406 from MLL and 321 from ABI-1); NH2- AT-hook, DNA methyltransferase, and transcriptional repression domain of MLL, fused to the homeodomain homologous region and the SH3 domain of ABI-1 in COOH. |
| External links |
| Other database | t(10;11)(p11.2;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(10;11)(p11.2;q23) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). |
| Taki T, Shibuya N, Taniwaki M, Hanada R, Morishita K, Bessho F, Yanagisawa M, Hayashi Y |
| Blood. 1998 ; 92 (4) : 1125-1130. |
| PMID 9694699 |
| t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines. |
| Shibuya N, Taki T, Mugishima H, Chin M, Tsuchida M, Sako M, Kawa K, Ishii E, Miura I, Yanagisawa M, Hayashi Y |
| Genes, chromosomes & cancer. 2001 ; 32 (1) : 1-10. |
| PMID 11477655 |
| Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia? |
| Morerio C, Rosanda C, Rapella A, Micalizzi C, Panarello C |
| Cancer genetics and cytogenetics. 2002 ; 139 (1) : 57-59. |
| PMID 12547160 |
| Contributor(s) |
| Written | 04-2000 | Jean-Loup Huret |
| Updated | 01-2006 | Cristina Morerio, Claudio Panarello |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(10;11)(p11.2;q23). Atlas Genet Cytogenet Oncol Haematol. April 2000 . URL : http://AtlasGeneticsOncology.org/Genes/t1011ID1178.html |
| Morerio C, Panarello C . t(10;11)(p11.2;q23). Atlas Genet Cytogenet Oncol Haematol. January 2006 . URL : http://AtlasGeneticsOncology.org/Genes/t1011ID1178.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Sep 24 21:07:15 2008 |
For comments and suggestions or contributions, please contact us