t(12;17)(p11;q11) in AML

2006-11-01 David Betts Affiliation

1.Department of Oncology, University Childrens Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

Acute myeloid leukaemia (AML)

The appearance of the translocation may resemble the rare non-random t(12;17)(p13;q11-21) associated with ALL.

Very rare translocation reported in three adults and one child with secondary AML following an ALL. The four published cases have been female.

Insufficient data to indicate a prognostic significance.

Note

No report of any molecular or FISH data to elucidate exact breakpoint or genes.

Pubmed ID	Last Year	Title	Authors
1384679	1992	Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG).
12923315	2003	Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia.	Brozek I et al
11165315	2001	Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping.	Kerndrup GB et al
2331674	1990	Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.	Sun GX et al

David Betts

t(12;17)(p11;q11) in AML

Atlas Genet Cytogenet Oncol Haematol. 2006-11-01

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