t(12;17)(p13;q11-21) in ALL
2006-04-01 David Betts Affiliation1.Department of Oncology, University Childrens Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland
Clinics and Pathology
Disease
Acute lymphoblastic leukaemia (ALL)
Note
Identical or similar translocations have been reported rarely in acute myeloid leukemia (AML) and acute mixed lineage leukaemia ( t(12;17)(p13;q11-21) in AML ).
Phenotype stem cell origin
Most reports indicate an early pre-B immunophenotype, frequently characterised by low CD10 and positivity of the myeloid marker CD33.
Epidemiology
Rare; non-random translocation that predominantly occurs in children and young adults. No definable sex bias.
Prognosis
Early reports suggested that prognosis may be poor, but there are currently too few reported cases to define a robust association.
Cytogenetics
Cytogenetics morphological
The chromosome 17q breakpoint has been defined in different reports to be between q11-q21. The chromosome 12 breakpoint has been confirmed to be located in 12p13 telomeric to the ETV6/TEL locus. The translocation occurs as the sole or primary event in approximately 50% of cases
Additional anomalies
No consistent picture and only +21 has been reported in more than one case.
Genes Involved and Proteins
Note
Breakpoint on 12p13 telomeric to TEL. Currently the genes involved on both chromosome 12 and 17 are unidentified.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 1534130 | 1992 | t(12;17)(p13;q21) in early pre-B acute lymphoid leukemia. | Krance RA et al |
| 1458446 | 1992 | Translocation (12;17)(p11-12;q11-12): a recurrent primary rearrangement in acute leukemia. | Liu HW et al |
| 16490598 | 2006 | A t(12;17)(p13;q12) identifies a distinct TEL rearrangement-negative subtype of precursor-B acute lymphoblastic leukemia. | Reid AG et al |
| 11801311 | 2002 | Fluorescence in situ hybridization analysis of the cryptic t(12;21) (p13;q22) in childhood B-lineage acute lymphoblastic leukemia. | Yehuda-Gafni O et al |
Citation
David Betts
t(12;17)(p13;q11-21) in ALL
Atlas Genet Cytogenet Oncol Haematol. 2006-04-01
Online version: http://atlasgeneticsoncology.org/haematological/1072/t(12;17)(p13;q11-21)-in-all
