| Disease | Acute myeloid leukaemia (AML) |
| Phenotype / cell stem origin | Myeloid leukaemias (Paietta et al., 1988; Scheurlen et al., 1999), if we exclude a case of lymphoplasmacytoid lymphoma (Offit el al., 1995). The translocation is found in M1-AML and M2-AML, with erythroid hyperplasia in the bone marrow and the presence of binucleated and trinucleated red cells in at least 3 of 4 cases (Paietta et al., 1988). |
| Epidemiology | Four cases available, 2 male and 2 female patients, aged 26, 61, 63, and 63. |
| Prognosis | The clinical outcome is poor, with 2 cases not entering into remission and dead within 2 months after diagnosis, and a third patient with partial remission, relapse after 2 months, and death. The fourth patient's outcome is unknown. |
| Translocation t(12;19)(q13;q13.3). A new recurrent abnormality in acute nonlymphocytic leukemia with atypical erythropoiesis. |
| Paietta E, Papenhausen P, Gucalp R, Wiernik PH. |
| Cancer Genet Cytogenet. 1988 Aug;34(1):19-23. |
| PMID 3395990 |
| |
| Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features. |
| Offit K, Louie DC, Parsa NZ, Noy A, Chaganti RS. |
| Blood. 1995 Sep 15;86(6):2365-70. |
| PMID 7662983 |
| |
| Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q). |
| Scheurlen WG, Schwabe GC, Seranski P, Joos S, Harbott J, Metzke S, Dohner H, Poustka A, Wilgenbus K, Haas OA. |
| Genes Chromosomes Cancer. 1999 Jul;25(3):230-40. |
| PMID 10379869 |
| |