| Clinics and Pathology |
| Disease | myeloid and lymphoid lineages (myelodysplastic syndromes (MDS), acute nonlymphocytic leukaemia (ANLL), acute lymphocytic leukaemia (ALL), chronic lymphocytic leukaemia (CLL)); also reported in patients free of haematological malignancy |
| Phenotype / cell stem origin | most commonly seen in low grade MDS, usually RA |
| Epidemiology | frequency: rare; marked male predominance; found mostly in adults; med age: 77 |
| Prognosis | not known |
| Cytogenetics |
| Additional anomalies | sex chromosome aneuploidy, particularly -Y in males |
| Genes involved and Proteins |
| Note | is/are not known |
| External links |
| Other database | +15 or trisomy 15 (as sole autosomal abnormality) | Mitelman database (CGAP - NCBI) |
| To be noted |
| proposed association between loss of Y chromosome and trisomy 15, which may reflect an underlying age effect in some cases |
| Bibliography |
| Trisomy 15 in hematological malignancies: six cases and review of the literature. |
| Smith SR, Rowe D |
| Cancer genetics and cytogenetics. 1996 ; 89 (1) : 27-30. |
| PMID 8689605 |
| Trisomy 15 associated with loss of the Y chromosome in bone marrow: a possible new aging effect. |
| Sinclair EJ, Potter AM, Watmore AE, Fitchett M, Ross F |
| Cancer genetics and cytogenetics. 1998 ; 105 (1) : 20-23. |
| PMID 9689925 |
| Contributor(s) |
| Written | 05-1999 | Elizabeth J Sinclair and Anthony M Potter |
| Centre for Human Genetics, Sheffield, United Kingdom |
| Citation |
| This paper should be referenced as such : |
| Sinclair EJ and Potter AM . +15 or trisomy 15 (as sole autosomal abnormality). Atlas Genet Cytogenet Oncol Haematol. May 1999 . URL : http://AtlasGeneticsOncology.org/Anomalies/tri15ID1144.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jul 3 11:54:43 CEST 2010 |
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