+15 or trisomy 15 (as sole autosomal abnormality)
1999-05-01 Elizabeth J Sinclair , Anthony M Potter Affiliation1.Centre for Human Genetics, Sheffield, United Kingdom
Clinics and Pathology
Disease
myeloid and lymphoid lineages (myelodysplastic syndromes (MDS), acute nonlymphocytic leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic lymphocytic leukaemia (CLL)); also reported in patients free of haematological malignancy
Phenotype stem cell origin
most commonly seen in low grade MDS, usually RA
Epidemiology
frequency: rare; marked male predominance; found mostly in adults; med age: 77
Prognosis
not known
Genes Involved and Proteins
Note
is/are not known
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9689925 | 1998 | Trisomy 15 associated with loss of the Y chromosome in bone marrow: a possible new aging effect. | Sinclair EJ et al |
| 8689605 | 1996 | Trisomy 15 in hematological malignancies: six cases and review of the literature. | Smith SR et al |
Citation
Elizabeth J Sinclair ; Anthony M Potter
+15 or trisomy 15 (as sole autosomal abnormality)
Atlas Genet Cytogenet Oncol Haematol. 1999-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1144/+15-or-trisomy-15-(as-sole-autosomal-abnormality)
