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+9 or trisomy 9

Written2006-09Ulrike Bacher, Claudia Haferlach
Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany

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ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1020
Note Occurs in a large spectrum of myeloid and lymphatic malignancies - chronic myeloproliferative disorders (CMPD), acute myeloid leukemias (AML), myelodysplastic syndromes (MDS), acute lymphoblastic leukemias (ALL) of B-lineage and of T-lineage. Strong association to the CMPD and especially to polycythemia vera (PV).
  +9 (G-banding)

Clinics and Pathology

Disease B-lineage acute lymphoblastic leukemia
Epidemiology Rare in Philadelphia-positive and in Philadelphia-negative B-lineage.
Cytogenetics Additional anomalies: Philadelphia-negative ALL: Occurrence in hyperdiploid karyotypes (equal or more than 47 chromosomes) mostly in combination with other numerical gains. Philadelphia-positive ALL: Rare additional change.
Genes Not known.
Prognosis Philadelphia-negative ALL with high hyperdiploid karyotype (equal or more than 51 chromosomes) shows a good prognosis, gain of chromosome 9 is not typical and prognostic impact of trisomy 9 in this setting unknown. In Philadelphia-positive ALL additional chromosomal anomalies probably enhance the inferior prognosis.

Disease T-lineage acute lymphoblastic leukemia.
Epidemiology Rare, up to 4% in childhood T-ALL.
Cytogenetics Additional anomalies: Occurs as sole or as combined anomaly.
Genes Not known.
Prognosis So far a prognostic impact could not be defined, which also might be due to the low analyzed case numbers.


  +9 (chromosome painting, WCP#9 (red))


Conventional cytogenetics of myeloproliferative diseases other than CML contribute valid information.
Bacher U, Haferlach T, Kern W, Hiddemann W, Schnittger S, Schoch C
Annals of hematology. 2005 ; 84 (4) : 250-257.
PMID 15692838
Chromosome and molecular abnormalities in myelodysplastic syndromes.
Fenaux P
International journal of hematology. 2001 ; 73 (4) : 429-437.
PMID 11503956
Numerical chromosome aberrations in human neoplasia.
Heim S, Mitelman F
Cancer genetics and cytogenetics. 1986 ; 22 (2) : 99-108.
PMID 3708552
Karyotypic patterns in chronic myeloproliferative disorders: report on 74 cases and review of the literature.
Mertens F, Johansson B, Heim S, Kristoffersson U, Mitelman F
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1991 ; 5 (3) : 214-220.
PMID 2013980
Exploring polycythaemia vera with fluorescence in situ hybridization: additional cryptic 9p is the most frequent abnormality detected.
Najfeld V, Montella L, Scalise A, Fruchtman S
British journal of haematology. 2002 ; 119 (2) : 558-566.
PMID 12406101
Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia.
Rieder H, Ludwig WD, Gassmann W, Maurer J, Janssen JW, Gökbuget N, Schwartz S, Thiel E, Löffler H, Bartram CR, Hoelzer D, Fonatsch C
British journal of haematology. 1996 ; 95 (4) : 678-691.
PMID 8982045
New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases.
Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ, Camitta BM, Katz JA, Amylon MD
Blood. 2000 ; 96 (7) : 2543-2549.
PMID 11001909
The role of the JAK2 mutations: A study in 1103 patients with CMPD and in 196 patients with AML.
Schnittger S, Bacher U, Petrides P, Kern W, Haferlach T, Schoch C
Leukemia, submitted. 2006.


This paper should be referenced as such :
Haferlach, C ; Bacher, U
+9 or trisomy 9
Atlas Genet Cytogenet Oncol Haematol. 2007;11(1):40-41.
Free journal version : [ pdf ]   [ DOI ]
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External links

arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9837/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
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