+14 or trisomy 14 (solely)

Clinics and Pathology

Disease	myeloid disorders: MDS in more than half cases, ANLL in 1/4 of cases, chronic myeloproliferative syndrome ('atypical CML'); exceptionally: lymphoproliferations; therefore, only trisomy 14 solely in myeloid malignanies is herein described
Phenotype / cell stem origin	MDS: RA, RAEBħT mainly; ANLL: M1, M2, M4; atypical CML: with dysplastic features
Epidemiology	median age 60-65 yrs (range: 4-89 yrs); sex ratio: 4M/3F
Clinics	no history of carcinogen exposure of note; blood data: platelets count: 130 X 109/l; monocytosis in half cases
Cytology	all FAB subtypes of MDS can be found; atypical CML cases present with dysplastic features; non-lobulated megakaryocytes are often found
Prognosis	survival < 2yrs in most cases; +14 do not seem to bear a distinct prognosis

Cytogenetics

Cytogenetics Morphological	most often (90% of cases) in mosaic with normal cells
Cytogenetics Molecular	chromosome painting (although +14 detection attempts are, so far, not relevant)
Additional anomalies	none, at least in the sub-clone with '+14 solely', by that very fact; most often none in karyotype follow-up
Variants	may be found as i(14q)

Genes involved and Proteins

Note	genes involved are unknown

External links

Other database	+14 or trisomy 14 (solely)	Mitelman database (CGAP - NCBI)

Bibliography

Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies.

Toze CL, Barnett MJ, Naiman SC, Horsman DE

British journal of haematology. 1997 ; 98 (1) : 177-185.

PMID 9233582

Four additional cases of trisomy 14 as the sole anomaly in various haematological malignancies.

Brizard A, Guilhot F, Babin P, Burucoa C, Tanzer J, Huret JL

Leukemia research. 1992 ; 16 (5) : 537-540.

PMID 1625480

Contributor(s)

Written	08-1997	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . +14 or trisomy 14 (solely). Atlas Genet Cytogenet Oncol Haematol. August 1997 . URL : http://AtlasGeneticsOncology.org/Genes/tri_14.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Sep 24 21:07:48 2008

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