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+14 or trisomy 14 (solely)

Written1997-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1034

Clinics and Pathology

Disease myeloid disorders: MDS in more than half cases, AML in 1/4 of cases, chronic myeloproliferative syndrome ('atypical CML'); exceptionally: lymphoproliferations; therefore, only trisomy 14 solely in myeloid malignanies is herein described
Phenotype / cell stem origin MDS: RA, RAEB±T mainly; AML: M1, M2, M4; atypical CML: with dysplastic features
Epidemiology median age 60-65 yrs (range: 4-89 yrs); sex ratio: 4M/3F
Clinics no history of carcinogen exposure of note; blood data: platelets count: 130 X 109/l; monocytosis in half cases
Cytology all FAB subtypes of MDS can be found; atypical CML cases present with dysplastic features; non-lobulated megakaryocytes are often found
Prognosis survival < 2yrs in most cases; +14 do not seem to bear a distinct prognosis


Cytogenetics Morphological most often (90% of cases) in mosaic with normal cells
Cytogenetics Molecular chromosome painting (although +14 detection attempts are, so far, not relevant)
Additional anomalies none, at least in the sub-clone with '+14 solely', by that very fact; most often none in karyotype follow-up
Variants may be found as i(14q)

Genes involved and Proteins

Note genes involved are unknown


Four additional cases of trisomy 14 as the sole anomaly in various haematological malignancies.
Brizard A, Guilhot F, Babin P, Burucoa C, Tanzer J, Huret JL
Leukemia research. 1992 ; 16 (5) : 537-540.
PMID 1625480
Trisomy 14 is a non-random karyotypic abnormality associated with myeloid malignancies.
Toze CL, Barnett MJ, Naiman SC, Horsman DE
British journal of haematology. 1997 ; 98 (1) : 177-185.
PMID 9233582


This paper should be referenced as such :
Huret, JL
+14 or trisomy 14 (solely)
Atlas Genet Cytogenet Oncol Haematol. 1997;1(1):21-21.
Free journal version : [ pdf ]   [ DOI ]
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External links

arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
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