Chromosome 15

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ENTITIES: by Chromosome band

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Chromosome 15

[previous] 15 15p 15q 15p13 15p12 15p11 15q11 15q12 15q13 15q14 15q15 15q21 15q22 15q23 15q24 15q25 15q26 [next]

Band 15p11

chr15:9700000-19000000 (9300 Kb)

Chromosomal abnormalities in band 15p11

Genes in band 15p11 (reference hg38)

External links

References

Chromosomal abnormalities in band 15p11

(click on headers to reorder columns)

Band 1	Band 2	Class	Entity	Partner 1	Links	Topography	Morphology	[PubMed]	[Study]
15p11	15q11	Cosmic_SV	del(15)(p11q11)		Cosmic_SV [COST197879]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
15p11	15q14	Cosmic_SV	del(15)(p11q14)		Cosmic_SV [COST198488]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
15p11	15q14	Cosmic_SV	del(15)(p11q14)		Cosmic_SV [COST198717]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
15p11	15q22	Cosmic_SV	del(15)(p11q22)		Cosmic_SV [COST198009]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
		Mitelman	der(15)t(1;15)(q11;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
		Mitelman	der(15)t(1;15)(q11;p11)		Mitelman (CGAP)		Follicular lymphoma
		Mitelman	der(15)t(1;15)(q11;p11)		Mitelman (CGAP)		Refractory anemia
		Mitelman	der(15)t(1;15)(q12;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
		Mitelman	der(15)t(1;15)(q12;p11)		Mitelman (CGAP)		Multiple myeloma
		Mitelman	der(15)t(1;15)(q12;p11)		Mitelman (CGAP)		Refractory anemia with ringed sideroblasts
		Mitelman	der(15)t(15;17)(p11;q21)		Mitelman (CGAP)		Chronic lymphocytic leukemia
		Mitelman	der(15)t(5;15)(p11;p11)		Mitelman (CGAP)		Mantle cell lymphoma
1p11	15p11	Atlas - Leukemia	dic(1;15)(p11;p11)		dic0115p11p11ID1159		MPD::MDS::AML	[Biblio]
		Mitelman	dic(12;15)(p11;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
		Mitelman	dic(15;17)(p11;p11)		Mitelman (CGAP)		Chronic lymphocytic leukemia
		Mitelman	dic(15;21)(p11;p11)		Mitelman (CGAP)		Acute myeloid leukemia, NOS
		Mitelman	dic(9;15)(p11;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
15p11		Cosmic_SV	dup(15)(p11)		Cosmic_SV [COST197286]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
15p11	15q14	Cosmic_SV	inv(15)(p11q14)		Cosmic_SV [COST195937]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
15p11	15q14	Cosmic_SV	inv(15)(p11q14)		Cosmic_SV [COST197072]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
15p11	15q15	Cosmic_SV	inv(15)(p11q15)		Cosmic_SV [COST198020]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
		Mitelman	t(1;15)(q11;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
		Mitelman	t(1;15)(q11;p11)		Mitelman (CGAP)		Follicular lymphoma
		Mitelman	t(1;15)(q11;p11)		Mitelman (CGAP)		Refractory anemia
		Mitelman	t(1;15)(q12;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
		Mitelman	t(1;15)(q12;p11)		Mitelman (CGAP)		Multiple myeloma
		Mitelman	t(1;15)(q12;p11)		Mitelman (CGAP)		Refractory anemia with ringed sideroblasts
		Mitelman	t(15;16)(p11;p11)		Mitelman (CGAP)		Multiple myeloma
		Mitelman	t(15;17)(p11;q21)		Mitelman (CGAP)		Chronic lymphocytic leukemia
		Mitelman	t(15;22)(p11;q11)		Mitelman (CGAP)	Breast	Adenocarcinoma
		Mitelman	t(15;22)(p11;q11)		Mitelman (CGAP)		Diffuse large B-cell lymphoma
		Mitelman	t(4;15)(p10;p11)		Mitelman (CGAP)		Acute lymphoblastic leukemia/lymphoblastic lymphoma
		Mitelman	t(5;15)(p11;p11)		Mitelman (CGAP)		Mantle cell lymphoma
		Mitelman	t(X;15;18)(p11;p11;q11)		Mitelman (CGAP)	Soft tissue	Synovial sarcoma
Xq13	15p11	dbCRID	t(X;15)(q13.3;p11)		10604			[PubMed]
Xq27	15p11	dbCRID	t(X;15)(q27.1;p11.2)		11461		Hemophilia B	[PubMed]
Xq28	15p11	dbCRID	t(X;15)(q28;p11.2)	AFF2	11171			[PubMed]

Genes in band 15p11

(click on headers to reorder columns)

GoldenPath hg38	Band 1	Band 2	Class	Clone	Fusion	Partner 1	Partner 2	Links	Topography	Morphology	Pubmed	Omim	Accession

[ Bold normal : A; Italic normal :G; Italic small : E ]

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 [previous] 15 15p 15q 15p13 15p12 15p11 15q11 15q12 15q13 15q14 15q15 15q21 15q22 15q23 15q24 15q25 15q26 [next]

External links

Mitelman Database [NCI] : Breakpoint 15p11

[ UCSC ][ enSembl ][ MapView - NCBI ][ 1000Genomes ][ EVS ][ CGWB ][ DGV ][ DBVar ][ OMIM ][ HapMap ][ DECIPHER ] [ ECARUCA ]
Gene Expression (MSigDB) in 15p11 [ HTC ] [ NCI ] [ INV ]

Global tables

Anomalies list (tabulated txt file)

Genes list (tabulated txt file)

Anomalies list - limited to abnormalities with gene fusions(tabulated txt file)

Genes list - limited to genes fusions (tabulated txt file)

list of gene fusions for each gene (with origins of the data)

list of gene fusions by origin (with topography and morphology)

The human genome used in these documents corresponds to the hg38 (Build GRCh38). A more precise informtion about assemby can be found at Human genome Overview.
The limits of cytogenetic bands correspond to data from UCSC : cytoBand.txt.gz

ISCN Abbreviated Terms and Symbols [NCI]

[A]Atlas - Annotated genes

[G]Atlas - Other Genes

[F] fishClones (hg38)

[M] Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer [ CGAP Jul 2019]
and "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer" (2012). Mitelman F, Johansson B and Mertens F (Eds.)" [Sept 2016]

[N] Mitelman Database of Chromosome Aberrations (/number)

[COS] Catalogue Of Somatic Mutations In Cancer [v90]

[COF] Catalogue Of Somatic Mutations In Cancer : Gene Fusions [v90] [PubMed 2017]

[CSV] Catalogue Of Somatic Mutations In Cancer : Structural variations (extracted frorm CosmicStructExport.tsv) [v90]) [PubMed 2014]

[CEN] Cancer Gene Census [v90]

[TF] [PubMed 2014]TCGA Fusions (MDAndersson) TCGA Fusions (Jackson Lab) [PubMed 2014] (the fusions are limited to tiers 1 and 2)

[TIC] [PubMed 2007] TicDB

[H2] [PubMed 2006] ChimerDB_2.0

[H3] [PubMed 2010] [PubMed 2017] ChimerDB_3.0 [PubMed 2017]

[K] [PubMed 2011] dbCRID

[CT] [PubMed 2011] [PubMed 2012] [PubMed 2014] ChiTARS-2.1 [PubMed 2016] ChiTARS-3.1

[LAI] [PubMed 2015] Fusion transcript loci share many genomic Features with non-fusion loci. Lai et al. BMC Genomics 2015

[PM] Gene Fusions from Pubmed abstract mining

[L] [PubMed 2011] Fusion gene microarray reveals cancer type-specificity among fusion genes. Lovf M et al.Genes Chromosomes Cancer. 2011 May;50(5):348-57.

[S] [PubMed 21009] A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis. Skotheim RI, et al. Mol Cancer. 2009 Jan 19;8:5.

[V][PubMed 2012] ETV6 fusion genes in hematological malignancies: A review. De Braekeleer E. et al. Leuk Res. 2012 May 12.

[GT] [Pubmed 2015] Cell Lines (Genentech) Nature Biotech Suppl.Table8

[FC] [PubMed 2015] Fusion cancer (Beijing) (the fusions are limited to class A and B)

[NOR] [PubMed 2016] Babiceanu M et al. Recurrent chimeric fusion RNAs in non-cancer tissues and cells. Nucleic Acids Res. 2016 Feb 2 (Table S3)

[URK] [PubMed 2016] Urakami et al. Next generation sequencing approach for detecting 491 fusion genes from human cancer. Biomed Res. 2016;37(1):51-62.

[AM] [PubMed 2016] Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancersAlaei-Mahabadi B. et al.,Proc Natl Acad Sci U S A. 2016 Nov 16. pii: 201606220.

[FM] [PubMed 2018] Genomic hotspots but few recurrent fusion genes in breast cancer, Fimereli et al., Genes Chromosomes Cancer. (SupplTableS2.xls) 2018 Feb 13

[MA] [PubMed 2018] Pan-cancer genome and transcriptome analyses of1,699 paediatric leukaemias and solid tumours, Ma et al, Nature (March 2018) Table S3

[GAO] [PubMed 2018] Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. Gao et al, Cell Reports (April 2018) Table S2

[MAY] [PubMed 2018] Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumor, Winters et al (July 2018) Table S7

[GDB] [PubMed 2019] Fusion gene annotation DataBase. Kim P t Zhou X. Nucleic Acids Res. 2019 Jan 8;47(D1):D994-D1004 [site FusionGDB]

[DDR][DDG] [PubMed 2019] Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers, Dehghannasiri R et al, Proc Natl Acad Sci U S A. 2019 Jul 15. pii: 201900391. doi: 10.1073/pnas.1900391116

[DDR] TGCA novel recurrent fusions - Sup. Table 1

[DDG] GTEx (normal tissus) recurrent fusions - Sup. Table 1

Contributor(s)

Written may 2012 Philippe Dessen

Updated sept. 2019 Philippe Dessen and Jean-Loup Huret

Citation

This paper should be referenced as such :
Dessen P and Huret JL. Chromosomal band 15p11. Atlas Genet Cytogenet Oncol Haematol. July 2012.
URL : http://atlasgeneticsoncology.org/Bands/15p11.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : mer. sept. 25 14:06:59 CEST 2019

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case reports Journals Portal Teaching

Written	may 2012	Philippe Dessen

Updated	sept. 2019	Philippe Dessen and Jean-Loup Huret