Chromosome 21

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ENTITIES: by Chromosome band

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22

Chromosome 21

[previous] 21 21p 21q 21p13 21p12 21p11 21q11 21q21 21q22 [next]

Band 21p12

chr21:3100000-7000000 (3900 Kb)

Chromosomal abnormalities in band 21p12

Genes in band 21p12 (reference hg38)

External links

References

Chromosomal abnormalities in band 21p12

(click on headers to reorder columns)

Band 1	Band 2	Class	Entity	Partner 1	Links	Topography	Morphology	[PubMed]	[Study]
21p12	21q11	Cosmic_SV	del(21)(p12q11)		Cosmic_SV [COST197761]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q21	Cosmic_SV	del(21)(p12q21)		Cosmic_SV [COST195866]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q21	Cosmic_SV	del(21)(p12q21)		Cosmic_SV [COST197156]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q21	Cosmic_SV	del(21)(p12q21)		Cosmic_SV [COST197535]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST195912]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST198198]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST198428]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST198568]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST198905]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST199236]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	del(21)(p12q22)		Cosmic_SV [COST199350]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12		Cosmic_SV	dup(21)(p12)		Cosmic_SV [COST196360]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12		Cosmic_SV	dup(21)(p12)		Cosmic_SV [COST197310]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	inv(21)(p12q22)		Cosmic_SV [COST197155]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	21q22	Cosmic_SV	inv(21)(p12q22)		Cosmic_SV [COST198583]	prostate__NS	carcinoma__adenocarcinoma		[COSU537]
21p12	22q11	dbCRID	t(21;22)(p12;q11.21)	NM_007098.2	12077		DiGeorge Syndrome, Velocardiofacial Syndrome	[PubMed]

Genes in band 21p12

(click on headers to reorder columns)

GoldenPath hg38	Band 1	Band 2	Class	Clone	Fusion	Partner 1	Partner 2	Links	Topography	Morphology	Pubmed	Omim	Accession

[ Bold normal : A; Italic normal :G; Italic small : E ]

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 [previous] 21 21p 21q 21p13 21p12 21p11 21q11 21q21 21q22 [next]

External links

Mitelman Database [NCI] : Breakpoint 21p12

[ UCSC ][ enSembl ][ MapView - NCBI ][ 1000Genomes ][ EVS ][ CGWB ][ DGV ][ DBVar ][ OMIM ][ HapMap ][ DECIPHER ] [ ECARUCA ]
Gene Expression (MSigDB) in 21p12 [ HTC ] [ NCI ] [ INV ]

Global tables

Anomalies list (tabulated txt file)

Genes list (tabulated txt file)

Anomalies list - limited to abnormalities with gene fusions(tabulated txt file)

Genes list - limited to genes fusions (tabulated txt file)

list of gene fusions for each gene (with origins of the data)

list of gene fusions by origin (with topography and morphology)

The human genome used in these documents corresponds to the hg38 (Build GRCh38). A more precise informtion about assemby can be found at Human genome Overview.
The limits of cytogenetic bands correspond to data from UCSC : cytoBand.txt.gz

ISCN Abbreviated Terms and Symbols

[A]Atlas - Annotated genes

[G]Atlas - Other Genes

[F] fishClones (hg38)

[M] Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer [ Oct 2020 ]
and "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer" (2012). Mitelman F, Johansson B and Mertens F (Eds.)" [Sept 2016]

[N] Mitelman Database of Chromosome Aberrations (/number)

[COS] Catalogue Of Somatic Mutations In Cancer [v92]

[COF] Catalogue Of Somatic Mutations In Cancer : Gene Fusions [v92] [PubMed 2017]

[CSV] Catalogue Of Somatic Mutations In Cancer : Structural variations (extracted frorm CosmicStructExport.tsv) [v92) [PubMed 2014]

[CEN] Cancer Gene Census [v92]

[TF] [PubMed 2014]TCGA Fusions (MDAndersson) TCGA Fusions (Jackson Lab) [PubMed 2014] (the fusions are limited to tiers 1 and 2)

[TIC] [PubMed 2007] TicDB

[H2] [PubMed 2006] ChimerDB_2.0

[H3] [PubMed 2010] [PubMed 2017] ChimerDB_3.0

[H4] ChimerDB4 [PubMed 2017]

[K] [PubMed 2011] dbCRID

[CT] [PubMed 2011] [PubMed 2012] [PubMed 2014] ChiTARS-2.1 [PubMed 2016] ChiTARS-3.1

[LAI] [PubMed 2015] Fusion transcript loci share many genomic Features with non-fusion loci. Lai et al. BMC Genomics 2015

[PM] Gene Fusions from Pubmed abstract mining

[L] [PubMed 2011] Fusion gene microarray reveals cancer type-specificity among fusion genes. Lovf M et al.Genes Chromosomes Cancer. 2011 May;50(5):348-57.

[S] [PubMed 21009] A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis. Skotheim RI, et al. Mol Cancer. 2009 Jan 19;8:5.

[V][PubMed 2012] ETV6 fusion genes in hematological malignancies: A review. De Braekeleer E. et al. Leuk Res. 2012 May 12.

[GT] [Pubmed 2015] Cell Lines (Genentech) Nature Biotech Suppl.Table8

[FC] [PubMed 2015] Fusion cancer (Beijing) (the fusions are limited to class A and B)

[NOR] [PubMed 2016] Babiceanu M et al. Recurrent chimeric fusion RNAs in non-cancer tissues and cells. Nucleic Acids Res. 2016 Feb 2 (Table S3)

[URK] [PubMed 2016] Urakami et al. Next generation sequencing approach for detecting 491 fusion genes from human cancer. Biomed Res. 2016;37(1):51-62.

[AM] [PubMed 2016] Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancersAlaei-Mahabadi B. et al.,Proc Natl Acad Sci U S A. 2016 Nov 16. pii: 201606220.

[FM] [PubMed 2018] Genomic hotspots but few recurrent fusion genes in breast cancer, Fimereli et al., Genes Chromosomes Cancer. (SupplTableS2.xls) 2018 Feb 13

[MA] [PubMed 2018] Pan-cancer genome and transcriptome analyses of1,699 paediatric leukaemias and solid tumours, Ma et al, Nature (March 2018) Table S3

[GAO] [PubMed 2018] Driver Fusions and Their Implications in the Development and Treatment of Human Cancers. Gao et al, Cell Reports (April 2018) Table S2

[MAY] [PubMed 2018] Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumor, Winters et al (July 2018) Table S7

[GDB] [PubMed 2019] Fusion gene annotation DataBase. Kim P t Zhou X. Nucleic Acids Res. 2019 Jan 8;47(D1):D994-D1004 [site FusionGDB]

[DDR][DDG] [PubMed 2019] Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers, Dehghannasiri R et al, Proc Natl Acad Sci U S A. 2019 Jul 15. pii: 201900391. doi: 10.1073/pnas.1900391116

[DDR] TGCA novel recurrent fusions - Sup. Table 1

[DDG] GTEx (normal tissus) recurrent fusions - Sup. Table 1

[PC] PCAWG : Pan-cancer analysis of whole genomes. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. [PubMed 2020] gene fusion data on synapse syn10003873)

Contributor(s)

Written may 2012 Philippe Dessen

Updated nov. 2020 Philippe Dessen and Jean-Loup Huret

Citation

This paper should be referenced as such :
Dessen P and Huret JL. Chromosomal band 21p12. Atlas Genet Cytogenet Oncol Haematol. July 2012.
URL : http://atlasgeneticsoncology.org/Bands/21p12.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : lun. nov. 30 10:28:00 CET 2020

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case reports Journals Portal Teaching

Written	may 2012	Philippe Dessen

Updated	nov. 2020	Philippe Dessen and Jean-Loup Huret