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MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6)

Identity

Other namesAF17 (ALL1 fused gene from chromosome 17)
HGNC (Hugo) MLLT6
Location 17q21
Location_base_pair Starts at 34115399 and ends at 34139582 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Local_order proximal to RARA, also in 17q21; HLF is even more distal in 17q22

DNA/RNA

Transcription 7.5 and 5 kb mRNA; coding sequence: 3.3 kb

Protein

Description 1093 amino acids; N- term - 3 Zn fingers (LAP type) and a leucine zipper - C-term; a leucine zipper is a dimerization motif
Localisation nuclear
Function transcriptional regulation factor
Homology with AF10 and BR140, a gene sitting in 3p25

Implicated in

Entity t(11;17)(q23;q21) /ANLL --> MLL-AF17
Disease ANLL and MDS
Cytogenetics additional anomaly: +8
Hybrid/Mutated Gene 5' MLL - 3' AF17
Abnormal Protein N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF17
  

External links

Nomenclature
HGNC (Hugo)MLLT6   7138
Entrez_Gene (NCBI)MLLT6  4302  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
Cards
AtlasAF17
GeneCards (Weizmann)MLLT6
Ensembl (Hinxton)ENSG00000108292 [Gene_View]  MLLT6 [Vega]
AceView (NCBI)MLLT6
Genatlas (Paris)MLLT6
euGene (Indiana)4302
SOURCE (Stanford)NM_005937
Genomic and cartography
GoldenPath (UCSC)MLLT6  -  17q21   chr17:34115399-34139582 +  17q21   [Description]    (hg18-Mar_2006)
EnsemblMLLT6 - 17q21 [CytoView]
Mapping of homologs : NCBIMLLT6 [Mapview]
OMIM600328   
Gene and transcription
Gene : Genbank (Entrez)AB209633 AF075118 AK027133 AK057058 AK092893
Reference sequence (RefSeq transcript) :SRSNM_005937
Reference transcript : EntrezNM_005937
RefSeq genomic : SRSAC_000060 AC_000149 NC_000017 NT_010755 NW_001838435 NW_926828
RefSeq genomic : EntrezAC_000060 AC_000149 NC_000017 NT_010755 NW_001838435 NW_926828
Consensus coding sequences : CCDS NCBIMLLT6
Cluster EST : UnigeneHs.605712 [ SRS ] Hs.605712 [ NCBI ]
Alternative Splicing : Fast-db (Paris)9323
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP55198 (SRS) P55198 (Expasy) P55198 (Uniprot)
With graphics : InterProP55198
Splice isoforms : VarSplice FASTAP55198(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domain pattern : Prosite (Expaxy)ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)   
Domains : Interpro (SRS)Znf_PHD   
Domains : Interpro (EBI)Znf_PHD   
Related proteins : CluSTrP55198
Domain families : Pfam SRSPHD (PF00628)   
Domain families : Pfam SangerPHD (PF00628)   
Domain families : Pfam NCBIpfam00628   
Domain families : Smart EMBLPHD (SM00249)
Blocks (Seattle)P55198
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD08978
Protein Interaction databases
DIP (DOE-UCLA)P55198
IntAct (EBI)P55198
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIMLLT6
SNP : GeneSNP UtahMLLT6
SNP : HGBaseMLLT6
Genetic variants : HAPMAPMLLT6
Somatic Mutations in Cancer : COSMICMLLT6 
Translocation Breakpoints in Cancer : TICdbMLLT6 
Mutations and Diseases : HGMDMLLT6
Hereditary diseases : OMIM600328   
Hereditary diseases : GENETests600328   
Diseases : Genetic AssociationMLLT6
General knowledge
Homologs : HomoloGeneMLLT6
Homology/Alignments : Family Browser UCSCMLLT6
Phylogenetic Trees/Animal Genes : TreeFamMLLT6
Chemical/Protein Interactions : CTD4302
Keywords Ontology : AmiGOprotein binding  nucleus  cytoplasm  mitochondrion  regulation of transcription, DNA-dependent  zinc ion binding  metal ion binding  
Keywords Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  mitochondrion  regulation of transcription, DNA-dependent  zinc ion binding  metal ion binding  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesMLLT6 Related clones (RZPD - Berlin)
Literature
PubMed7 Pubmed reference(s) in Entrez
PubGeneMLLT6

Bibliography

Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.
Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM, Canaani E
Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (17) : 8107-8111.
PMID 8058765
 
Chromosome abnormalities in leukaemia: the 11q23 paradigm.
Young BD, Saha V
Cancer surveys. 1996 ; 28 : 225-245.
PMID 8977038
 
Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.
Bernard OA, Berger R
Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85.
PMID 7542910
 
11q23 rearrangements in acute leukemia.
Rubnitz JE, Behm FG, Downing JR
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82.
PMID 8558942
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written12-1997Jean-Loup Huret

Citation

This paper should be referenced as such :
Huret JL . MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6). Atlas Genet Cytogenet Oncol Haematol. December 1997 .
URL : http://AtlasGeneticsOncology.org/Genes/AF17.html

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indexed on : Sat Jun 27 16:37:22 CEST 2009
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