MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6)

1997-12-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
17q12
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
FUSION GENES

DNA/RNA

Transcription

7.5 and 5 kb mRNA; coding sequence: 3.3 kb

Proteins

Description

1093 amino acids; N- term - 3 Zn fingers (LAP type) and a leucine zipper - C-term; a leucine zipper is a dimerization motif

Localisation

nuclear

Function

transcriptional regulation factor

Homology

with AF10 and BR140, a gene sitting in 3p25

Implicated in

Entity name
Disease
AML and MDS
Cytogenetics
additional anomaly: +8
Hybrid gene
5 MLL - 3 AF17
Fusion protein
N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF17

Bibliography

Pubmed IDLast YearTitleAuthors
75429101995Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.Bernard OA et al
80587651994Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.Prasad R et al
8558942199611q23 rearrangements in acute leukemia.Rubnitz JE et al
89770381996Chromosome abnormalities in leukaemia: the 11q23 paradigm.Young BD et al

Other Information

Locus ID:

NCBI: 4302
MIM: 600328
HGNC: 7138
Ensembl: ENSG00000275023

Variants:

dbSNP: 4302
ClinVar: 4302
TCGA: ENSG00000275023
COSMIC: MLLT6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275023ENST00000615858A0A087WVY1
ENSG00000275023ENST00000620609Q6P2C6
ENSG00000275023ENST00000621332P55198

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198644292009AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.23
160862882005[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].0

Citation

Jean-Loup Huret

MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6)

Atlas Genet Cytogenet Oncol Haematol. 1997-12-01

Online version: http://atlasgeneticsoncology.org/gene/7/mllt6