FOXO3 (forkhead box O3A)
1998-04-01 Olivier Bernard AffiliationUnite Inserm U434, CNRS, Institut de Genetique Moleculaire, Paris, France
Identity
HGNC
LOCATION
6q21
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
AF6q21,FKHRL1,FKHRL1P2,FOXO2,FOXO3A
FUSION GENES
DNA/RNA
Transcription
6 kb transcript with a 3.2 kb mRNA complete cds; coding sequence: CDS 925..2946
Proteins
Description
673 amino acids; NH2 -- similarity region with AFX and FKHR --
Forkhead motif -- COOH
Expression
wide
Localisation
nuclear (potential)
Function
may be a transcription regulator
Homology
AFX, involved in the t(X;11)(q13;q23), and
FHKR, involved in rabdomyosarcoma; with also a similar
breakpoint location within the forkhead motif
Implicated in
Entity name
Disease
treatment related AML, M5 type
Hybrid gene
5 MLL - 3 AF6q2
Fusion protein
240 kDa protein with about 1400 amino acids from N-term MLL fused
to 446 amino acids from AF6q21 C-term; the reciprocal may be expressed
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9479491 | 1998 | Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. | Anderson MJ et al |
| 9345057 | 1997 | AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. | Hillion J et al |
Other Information
Locus ID:
NCBI: 2309
MIM: 602681
HGNC: 3821
Ensembl: ENSG00000118689
Variants:
dbSNP: 2309
ClinVar: 2309
TCGA: ENSG00000118689
COSMIC: FOXO3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000118689 | ENST00000343882 | O43524 |
| ENSG00000118689 | ENST00000406360 | O43524 |
| ENSG00000118689 | ENST00000540898 | O43524 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37087718 | 2024 | The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a. | 1 |
| 37857267 | 2024 | Genetic Profile of FOXO3 Single-Nucleotide Polymorphism in Colorectal Cancer Patients. | 1 |
| 38009316 | 2024 | FOXO3 longevity genotype attenuates the impact of hypertension on cerebral microinfarct risk. | 1 |
| 38049565 | 2024 | FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis. | 2 |
| 38217540 | 2024 | ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis. | 0 |
| 38270719 | 2024 | FOXO3a-interacting proteins' involvement in cancer: a review. | 0 |
| 38286271 | 2024 | FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines. | 0 |
| 38332574 | 2024 | Helicobacter pylori CagA protein induces gastric cancer stem cell-like properties through the Akt/FOXO3a axis. | 2 |
| 38362840 | 2024 | EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway. | 0 |
| 38470367 | 2024 | CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis. | 1 |
| 38608123 | 2024 | The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer. | 0 |
| 38630149 | 2024 | circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy. | 0 |
| 38636197 | 2024 | FOXO3a deregulation in uterine smooth muscle tumors. | 0 |
| 37087718 | 2024 | The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a. | 1 |
| 37857267 | 2024 | Genetic Profile of FOXO3 Single-Nucleotide Polymorphism in Colorectal Cancer Patients. | 1 |
Citation
Olivier Bernard
FOXO3 (forkhead box O3A)
Atlas Genet Cytogenet Oncol Haematol. 1998-04-01
Online version: http://atlasgeneticsoncology.org/gene/125/foxo3
