ARMCX2 (arm protein lost in epithelial cancers, X chromosome, 2)

2003-07-01   Jean-Loup Huret  , Sylvie Senon  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
ARMCX2
LOCATION
Xq22.1
LOCUSID
9823
ALIAS
ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans 4.6 kb

Transcription

main transcript: 2.7 kb; other transcripts: 1.4 and 7 kb.

Proteins

Description

632 amino acids; contains a transmembrane domain in N term, and a arm (armadillo) repeat

Expression

wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas

Homology

with ALEX1 and ALEX3

Implicated in

Article Bibliography

Pubmed IDLast YearTitleAuthors
111625202001ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.Kurochkin IV et al

Other Information

Locus ID:

NCBI: 9823
MIM: 300363
HGNC: 16869
Ensembl: ENSG00000184867

Variants:

dbSNP: 9823
ClinVar: 9823
TCGA: ENSG00000184867
COSMIC: ARMCX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184867ENST00000328766Q7L311
ENSG00000184867ENST00000328766A0A024RCG7
ENSG00000184867ENST00000330154Q7L311
ENSG00000184867ENST00000330154A0A024RCG7
ENSG00000184867ENST00000356824Q7L311
ENSG00000184867ENST00000356824A0A024RCG7
ENSG00000184867ENST00000413506Q5H9E1
ENSG00000184867ENST00000431597Q5H9D7
ENSG00000184867ENST00000433318Q5H9E0
ENSG00000184867ENST00000440675A0A0B4J1X4
ENSG00000184867ENST00000458024A0A1B0GXK8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
326854722020ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.9
326854722020ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.9
222492492012Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.138
222492492012Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.138

Citation

Jean-Loup Huret ; Sylvie Senon

ARMCX2 (arm protein lost in epithelial cancers, X chromosome, 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-07-01

Online version: http://atlasgeneticsoncology.org/gene/478/armcx2