BCAS4 (breast carcinoma amplified sequence 4)

Identity

Other names	BHLHB4
	FLJ20495
HGNC	BCAS4
Location	20q13
Location_base_pair	Starts at 48844874 and ends at 48927121 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	spans 82 kb; orientation direct strand; 19 exons
Transcription	alternate splicings

Protein

Expression	ubiquitous
Localisation	cytoplasmic

Implicated in

Entity	BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid/Mutated Gene	5' BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript

External links

	Nomenclature
HGNC	BCAS4   14367
Entrez_Gene	BCAS4  55653  breast carcinoma amplified sequence 4
	Cards
Atlas	BCAS4ID767
GeneCards	BCAS4
Ensembl	BCAS4 [Search_View]   ENSG00000124243 [Gene_View]  BCAS4 [Vega]
Genatlas	BCAS4
GeneLynx	BCAS4
eGenome	BCAS4
euGene	55653
	Genomic and cartography
GoldenPath	BCAS4  -  20q13   chr20:48844874-48927121 +  20q13   [Description]    (hg18-Mar_2006)
Ensembl	BCAS4 - 20q13 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BCAS4
	Gene and transcription
Genbank	AF361220 [ ENTREZ ]
Genbank	AJ511266 [ ENTREZ ]
Genbank	AK000502 [ ENTREZ ]
Genbank	BC038381 [ ENTREZ ]
Genbank	BC047337 [ ENTREZ ]
RefSeq	NM_001010974 [ SRS ]    NM_001010974 [ ENTREZ ]
RefSeq	NM_017843 [ SRS ]    NM_017843 [ ENTREZ ]
RefSeq	NM_198799 [ SRS ]    NM_198799 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	AC_000152 [ SRS ]    AC_000152 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_011362 [ SRS ]    NT_011362 [ ENTREZ ]
RefSeq	NW_001838666 [ SRS ]    NW_001838666 [ ENTREZ ]
RefSeq	NW_927339 [ SRS ]    NW_927339 [ ENTREZ ]
CCDS	BCAS4 CCDS - NCBI
AceView	BCAS4 AceView - NCBI
Unigene	Hs.708239 [ SRS ]    Hs.708239 [ NCBI ]     HS708239 [ spliceNest ]
Fast-db	13476 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q8TDM0 [ SRS]    Q8TDM0 [ EXPASY ]     Q8TDM0 [ INTERPRO ]     Q8TDM0 [ UNIPROT ] Q8TDM0 [ VarSplice ]
CluSTr	Q8TDM0
Blocks	Q8TDM0
HPRD	06314
	Protein Interaction databases
DIP	Q8TDM0
IntAct	Q8TDM0
	Polymorphism : SNP, mutations, diseases
OMIM	607471    [ map ]
GENECLINICS	607471
SNP	BCAS4 [dbSNP-NCBI]
SNP	NM_001010974 [SNP-NCI]
SNP	NM_017843 [SNP-NCI]
SNP	NM_198799 [SNP-NCI]
SNP	BCAS4 [GeneSNPs - Utah]  BCAS4] [HGBASE - SRS]
HAPMAP	BCAS4 [HAPMAP]
COSMIC	BCAS4 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	BCAS4
Genetic Association	BCAS4
CDC HuGE	BCAS4
	General knowledge
Family Browser	BCAS4 [UCSC Family Browser]
SOURCE	NM_001010974
SOURCE	NM_017843
SOURCE	NM_198799
SMD	Hs.708239
SAGE	Hs.708239
GO	cytoplasm [Amigo]  cytoplasm
PubGene	BCAS4
TreeFam	BCAS4
CTD	55653 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BCAS4 Related clones (RZPD - Berlin)
	PubMed
PubMed	6 Pubmed reference(s) in Entrez

Bibliography

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.

Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH

The Journal of biological chemistry. 2004 ; 279 (9) : 8076-8083.

PMID 14634023

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	05-2004	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . BCAS4 (breast carcinoma amplified sequence 4). Atlas Genet Cytogenet Oncol Haematol. May 2004 . URL : http://AtlasGeneticsOncology.org/Genes/BCAS4ID767.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:37:38 2008