BCAS4 (breast carcinoma amplified sequence 4)
2004-05-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
20q13.13
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
CNOL
FUSION GENES
DNA/RNA
Description
spans 82 kb; orientation direct strand; 19 exons
Transcription
alternate splicings
Proteins
Expression
ubiquitous
Localisation
cytoplasmic
Implicated in
Entity name
BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid gene
5 BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 14634023 | 2004 | p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. | Melino G et al |
Other Information
Locus ID:
NCBI: 55653
MIM: 607471
HGNC: 14367
Ensembl: ENSG00000124243
Variants:
dbSNP: 55653
ClinVar: 55653
TCGA: ENSG00000124243
COSMIC: BCAS4
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 12378525 | 2002 | Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. | 52 |
| 12378525 | 2002 | Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. | 52 |
Citation
Jean-Loup Huret ; Sylvie Senon
BCAS4 (breast carcinoma amplified sequence 4)
Atlas Genet Cytogenet Oncol Haematol. 2004-05-01
Online version: http://atlasgeneticsoncology.org/gene/767/bcas4
