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BRAF (v-raf murine sarcoma viral oncogene homolog B1)

Written2004-09Enric Domingo, Simo Schwartz Jr
Oncologia Molecular i Envelliment, Centre d'Investigacions en Bioqumica i Biologia Molecular (CIBBIM) Hospital Universitari Vall d'Hebron Passeig Vall d'Hebron 119-129 Barcelona 08035, Catalonia, Spain

(Note : for Links provided by Atlas : click)

Identity

Alias_namesv-raf murine sarcoma viral oncogene homolog B
Alias_symbol (synonym)BRAF1
Other aliasv-raf murine sarcoma viral oncogene homolog B1
RAFB1
HGNC (Hugo) BRAF
LocusID (NCBI) 673
Atlas_Id 828
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 140732564 and ends at 140924928 bp from pter ( according to hg19-Feb_2009)  [Mapping BRAF.png]
Local_order Between the NDUFB2 and MRPS33 genes.
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP3 (7q36.1) / BRAF (7q34)AGK (7q34) / BRAF (7q34)AGTRAP (1p36.22) / BRAF (7q34)
AKAP9 (7q21.2) / BRAF (7q34)AP3B1 (5q14.1) / BRAF (7q34)ARMC10 (7q22.1) / BRAF (7q34)
ATG7 (3p25.3) / BRAF (7q34)BCL2L11 (2q13) / BRAF (7q34)BRAF (7q34) / AGK (7q34)
BRAF (7q34) / AKAP9 (7q21.2)BRAF (7q34) / AP3B1 (5q14.1)BRAF (7q34) / ATG7 (3p25.3)
BRAF (7q34) / BRAF (7q34)BRAF (7q34) / CIITA (16p13.13)BRAF (7q34) / FAM114A2 (5q33.2)
BRAF (7q34) / HIBADH (7p15.2)BRAF (7q34) / KIAA1549 (7q34)BRAF (7q34) / MACF1 (1p34.3)
BRAF (7q34) / MRPS33 (7q34)BRAF (7q34) / SLC26A4 (7q22.3)BRAF (7q34) / SND1 (7q32.1)
BRAF (7q34) / SUGCT (7p14.1)BTF3L4 (1p32.3) / BRAF (7q34)CCDC6 (10q21.2) / BRAF (7q34)
CCDC91 (12p11.22) / BRAF (7q34)CCNY (10p11.21) / BRAF (7q34)CDC27 (17q21.32) / BRAF (7q34)
CEP89 (19q13.11) / BRAF (7q34)CLCN6 (1p36.22) / BRAF (7q34)CUL1 (7q36.1) / BRAF (7q34)
CUX1 (7q22.1) / BRAF (7q34)DYNC1I2 (2q31.1) / BRAF (7q34)EPS15 (1p32.3) / BRAF (7q34)
ERC1 (12p13.33) / BRAF (7q34)ETFA (15q24.2) / BRAF (7q34)FAM114A2 (5q33.2) / BRAF (7q34)
FAM131B (7q34) / BRAF (7q34)FCHSD1 (5q31.3) / BRAF (7q34)FXR1 (3q26.33) / BRAF (7q34)
GATM (15q21.1) / BRAF (7q34)GHR (5p13.1) / BRAF (7q34)GNAI1 (7q21.11) / BRAF (7q34)
GTF2I (7q11.23) / BRAF (7q34)HERPUD1 (16q13) / BRAF (7q34)HIBADH (7p15.2) / BRAF (7q34)
KDM7A (7q34) / BRAF (7q34)KIAA1549 (7q34) / BRAF (7q34)KLHL7 (7p15.3) / BRAF (7q34)
LSM14A (19q13.11) / BRAF (7q34)MACF1 (1p34.3) / BRAF (7q34)MKRN1 (7q34) / BRAF (7q34)
MYRIP (3p22.1) / BRAF (7q34)MZT1 (13q21.33) / BRAF (7q34)NRF1 (7q32.2) / BRAF (7q34)
NUB1 (7q36.1) / BRAF (7q34)NUP214 (9q34.13) / BRAF (7q34)RAD18 (3p25.3) / BRAF (7q34)
RBMS3 (3p24.1) / BRAF (7q34)RNF130 (5q35.3) / BRAF (7q34)SLC12A7 (5p15.33) / BRAF (7q34)
SLC45A3 (1q32.1) / BRAF (7q34)SND1 (7q32.1) / BRAF (7q34)STMP1 (7q33) / BRAF (7q34)
TANK (2q24.2) / BRAF (7q34)TAX1BP1 (7p15.2) / BRAF (7q34)TRIM24 (7q33) / BRAF (7q34)
ZC3HAV1 (7q34) / BRAF (7q34)ZKSCAN1 (7q22.1) / BRAF (7q34)ZNF767P (7q36.1) / BRAF (7q34)
ZSCAN30 (18q12.2) / BRAF (7q34)

DNA/RNA

 
  Diagram of the BRAF gene. Exons are represented by boxes (in scale) transcribed and untranscribed sequences in blue and yellow, with exon numbers on top and number of base pairs at the bottom. Introns are represented by black bars (not in scale) and the number of base pairs indicated. The arrows show the ATG and the stop codons respectively.
Description The BRAF gene is composed of 18 exons spanning in a region of 190284 bp.
Transcription The transcribed mRNA has 2478 bp.
Pseudogene BRAF2 in Xq13.3

Protein

Note The real sequence A31 G32 A33 was erroneously considered R31 P32. As the A33 was missing in previous sequences, some articles have erroneously assigned wrong numbers to coding mutations and amino acids (i.e. V599E mutation instead of V600E).
 
  Diagram of the BRAF protein in scale. Numbers inside the blue boxes indicate the exon from which is translated each part of the protein. The three boxes inside represent the conserved regions of the protein with the ARAF and RAF-1 genes (CR1, CR2 and CR3). With green bars are represented three different domains: RBD (Ras binding domain), CRD (Cysteine-rich domain) and KD (Kinase domain). A conserved glycine motif (G-loop) in exon 11 is indicated with a red bar and the activation segment (AS) in exon 15 with a pink bar. The black arrows indicate the major phosphorylation sites of the protein. C: Carboxyl-terminal; N: Amino-terminal.
Description Amino acids: 766. Molecular Weight: 84436 Daltons. The BRAF gene is a proto-oncogene that belongs to the Serine/Threonine Kinase Family. It is also a member of the RAF Subfamily together with the ARAF and RAF1 genes.
Expression BRAF is expressed in most tissues with high expression in neuronal tissue.
Localisation Cytoplasmic.
Function BRAF is a serine/threonine kinase that belongs to the RAS/RAF/MEK/ERK/MAPK pathway, which is involved in the transduccion of mitogenic signals from the cell membrane to the nucleus. RAS is inactive when binded to GDP, but when it binds to GTP becomes active and promotes phosphorylation and activation of BRAF and the activation of the pathway signal. Several genes have been found to be activated by this pathway, among them, cyclin D1, cyclin D2 and cyclin D3 (self-sufficiency in growth), VEGF (angiogenesis), c-myc (insensitivity to antigrowth signals), b3-integrin (tissue invasion and metastasis) and mdm2 (apoptosis evasion, limitless replicative potential and angiogenesis).
Homology BRAF shares three conserved regions (CR1, CR2 and CR3) with the other two RAF genes: ARAF and RAF1. CR1, which has 131 aa, contains the cysteine-rich domain (CRD) and most of the Ras binding domain (RBD). These two domains bind to RAS-GTP. CR2, which has 16 aa, is rich in serine and threonine residues, including S365 as an inhibitory phosphorylation site. Finally CR3, which has 293 aa and has the kinase domain, contains also the G-loop GXGXXG motif (highly conserved in most of the human kinases), the activation segment and the regulatory phosphorylation sites S446, S447, D448, D449, T599 and S602.

Mutations

Note Single nucleotide polymorphism (SNP) found in BRAF: A1023G (P341P); A1227G (S409S); A1383G (Q461Q); A1797C (T599T); A1929G (G643G); G2272A (G758R).
Germinal No germinal mutations described.
Somatic BRAF presents somatic mutations in different sort of tumors, predominantly in malignant melanoma, sporadic colorectal tumors showing mismatch repair defects in microsatellites (MSI), low-grade ovarian serous carcinoma and thyroid papillary cancer. 80% of these mutations correspond to the hotspot transversion mutation T1799A that causes the amino acidic substitution V600E. The other 20% accounts for a wide variable range of missense mutations and all of them reside in the glycines of the G-loop in the exon 11 or in the activation segment in exon 15 near the V600. The mutation V600E confers transformant activity to the cells because it mimics the phosphorylation of T599 and/or S602 in the activation segment and so BRAF rests constitutively active in a RAS independent manner. Mutations in or NRAS are not concomitant with the BRAF mutation V600E. This mutation has not been found in other tumors like gastric cancer, endometrial cancer, uveal melanoma, biliary tract cancer or hepatocellular carcinoma..

Implicated in

Note
  
Entity Melanoma
Note BRAF is mutated in 70% of malignant melanomas. The mutation V600E is an early event and alone is insufficient for the development of melanoma as it is present in 80% of primary melanomas and 80% of nevi, which are the first lesions associated with this tumor. No BRAF mutations are associated with uveal melanoma.
 
Diagram with BRAF mutations found in melanoma. The black arrows indicate the mutations. The mutations inside a box are in the same amino acid. The hotspot mutation V600E is in red. Numbers inside the blue boxes indicate the exon from which is translated each part of the protein. The three boxes inside represent the conserved regions of the protein with the ARAF and RAF-1 genes (CR1, CR2 and CR3). A conserved glycine motif (G-loop) in exon 11 is indicated with a red bar and the activation segment (AS) in exon 15 with a pink bar. C: Carboxyl-terminal; N: Amino-terminal.
  
  
Entity Colorectal cancer
Note BRAF mutation V600E is associated with mismatch repair deficiency (MSI) and found in 40% of the cases while in mismatch repair proficient tumors (MSS) the frequency is around 5%. Gastric and endometrial MSI and MSS tumors do not have BRAF mutations. In sporadic MSI colon cases this mutation is found in proximal colon tumors with MLH1 methylation (80% of cases), while in tumors from the hereditary nonpolyposis colorectal cancer (HNPCC), either with MLH1, MSH2 or MSH6 germline mutations or none, no BRAF mutations are detected. Because of this it has been proposed the use of the BRAF V600E mutation for HNPCC diagnostic as a exclusion criteria for germline mutation in mismatch repair genes.
Prognosis Even though its association with sporadic MSI suggest BRAF as a good prognosis factor, it has been also associated to metastatic colorectal MSS cancers. In this cases, BRAF associates with poor prognosis.
 
Diagram with BRAF mutations found in colorectal cancer. The black arrows indicate the mutations. The mutations inside a box are in the same amino acid. The hotspot mutation V600E is in red. Numbers inside the blue boxes indicate the exon from which is translated each part of the protein. The three boxes inside represent the conserved regions of the protein with the ARAF and RAF-1 genes (CR1, CR2 and CR3). A conserved glycine motif (G-loop) in exon 11 is indicated with a red bar and the activation segment (AS) in exon 15 with a pink bar. C: Carboxyl-terminal; N: Amino-terminal.
  
  
Entity Ovarian cancer
Note The only BRAF mutation is V600E which is found in 30% of low-grade serous carcinoma and borderline tumors. The mutation seems to occur very early in the development. High-grade tumors do not show BRAF mutations.
  
  
Entity Thyroid cancer
Note In thyroid papillary cancer the only BRAF mutation present is V600E with a frequency around 50%. The K601E mutation has also been found in some cases of the follicular variant of thyroid cancer.
  
  
Entity cell lines
 
Mutations of BRAF in cell lines from colorectal cancer, gastric cancer, endometrial cancer, melanoma and thyroid cancer. It is indicated the MSI status and KRAS mutations in the colorectal, gastric and endometrial cell lines. NRAS mutations are indicated in melanoma and thyroid cell lines.
  

Bibliography

BRAF mutation in papillary thyroid carcinoma.
Cohen Y, Xing M, Mambo E, Guo Z, Wu G, Trink B, Beller U, Westra WH, Ladenson PW, Sidransky D
Journal of the National Cancer Institute. 2003 ; 95 (8) : 625-627.
PMID 12697856
 
Mutations of the BRAF gene in human cancer.
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA
Nature. 2002 ; 417 (6892) : 949-954.
PMID 12068308
 
Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.
Domingo E, Espín E, Armengol M, Oliveira C, Pinto M, Duval A, Brennetot C, Seruca R, Hamelin R, Yamamoto H, Schwartz S Jr
Genes, chromosomes & cancer. 2004 ; 39 (2) : 138-142.
PMID 14695993
 
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Domingo E, Laiho P, Ollikainen M, Pinto M, Wang L, French AJ, Westra J, Frebourg T, Espín E, Armengol M, Hamelin R, Yamamoto H, Hofstra RM, Seruca R, Lindblom A, Peltomäki P, Thibodeau SN, Aaltonen LA, Schwartz S Jr
Journal of medical genetics. 2004 ; 41 (9) : 664-668.
PMID 15342696
 
Raf proteins and cancer: B-Raf is identified as a mutational target.
Mercer KE, Pritchard CA
Biochimica et biophysica acta. 2003 ; 1653 (1) : 25-40.
PMID 12781369
 
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Oliveira C, Pinto M, Duval A, Brennetot C, Domingo E, Espín E, Armengol M, Yamamoto H, Hamelin R, Seruca R, Schwartz S Jr
Oncogene. 2003 ; 22 (57) : 9192-9196.
PMID 14668801
 
High frequency of BRAF mutations in nevi.
Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, Salem G, Pohida T, Heenan P, Duray P, Kallioniemi O, Hayward NK, Trent JM, Meltzer PS
Nature genetics. 2003 ; 33 (1) : 19-20.
PMID 12447372
 
Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis.
Shih IeM, Kurman RJ
The American journal of pathology. 2004 ; 164 (5) : 1511-1518.
PMID 15111296
 
BRAF as a potential therapeutic target in melanoma and other malignancies.
Tuveson DA, Weber BL, Herlyn M
Cancer cell. 2003 ; 4 (2) : 95-98.
PMID 12957284
 

Citation

This paper should be referenced as such :
Domingo, E ; Schwartz, S Jr
BRAF (v-raf murine sarcoma viral oncogene homolog B1
Atlas Genet Cytogenet Oncol Haematol. 2004;8(4):294-298.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/BRAFID828.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Follicular Dendritic Cell Sarcoma
t(5;7)(q31;q34) FCHSD1/BRAF


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 69 ]
  Colon: Colorectal adenocarcinoma
Thyroid: Medullary carcinoma
Kidney: Metanephric adenoma
Head and Neck: Primary oral mucosal melanoma
Pancreatic tumors: an overview
Thyroid: Papillary Carcinoma with inv(7)(q21q34) AKAP9/BRAF
Thyroid: Papillary carcinoma/Adenocarcinoma
Prostate tumors: an overview
Skin: Spitz tumors
t(1;7)(p32;q34) BTF3L4/BRAF
t(1;7)(p32;q34) EPS15/BRAF
t(1;7)(p34;q34) BRAF/MACF1
t(1;7)(p34;q34) BRAF/MACF1
t(1;7)(p34;q34) MACF1/BRAF
t(1;7)(p36;q34) AGTRAP/BRAF
t(1;7)(p36;q34) CLCN6/BRAF
t(1;7)(q32;q34) SLC45A3/BRAF
t(2;7)(q24;q34) TANK/BRAF
t(2;7)(q31;q34) DYNC1I2/BRAF
t(3;7)(p22;q34) MYRIP/BRAF
t(3;7)(p24;q34) RBMS3/BRAF
t(3;7)(p25;q34) ATG7/BRAF
t(3;7)(p25;q34) BRAF/ATG7
t(3;7)(p25;q34) RAD18/BRAF
t(3;7)(q26;q34) FXR1/BRAF
t(5;7)(p15;q34) SLC12A7/BRAF
t(5;7)(q14;q34) AP3B1/BRAF
t(5;7)(q14;q34) BRAF/AP3B1
t(5;7)(q33;q34) BRAF/FAM114A2
t(5;7)(q33;q34) FAM114A2/BRAF
t(5;7)(q35;q34) RNF130/BRAF
t(7;7)(p14;q34) BRAF/SUGCT
t(7;7)(p14;q34) SEPT7/BRAF
t(7;7)(p15;q34) BRAF/HIBADH
t(7;7)(p15;q34) HIBADH/BRAF
t(7;7)(p15;q34) KLHL7/BRAF
t(7;7)(p15;q34) TAX1BP1/BRAF
t(7;7)(p21;q34) TMEM106B/BRAF
t(7;7)(q11;q34) GTF2I/BRAF
t(7;7)(q11;q34) GTF2I/BRAF
t(7;7)(q21;q34) GNAI1/BRAF
t(7;7)(q22;q34) ARMC10/BRAF
t(7;7)(q22;q34) ARMC10/BRAF
t(7;7)(q22;q34) BRAF/SLC26A4
t(7;7)(q22;q34) CUX1/BRAF
t(7;7)(q22;q34) CUX1/BRAF
t(7;7)(q22;q34) ZKSCAN1/BRAF
t(7;7)(q32;q34) BRAF/SND1
t(7;7)(q32;q34) NRF1/BRAF
t(7;7)(q32;q34) SND1/BRAF
t(7;7)(q32;q34) SND1/BRAF
t(7;7)(q32;q34) SND1/BRAF
t(7;7)(q34;q36) AGAP3/BRAF
t(7;7)(q34;q36) AGAP3/BRAF
t(7;7)(q34;q36) NUB1/BRAF
t(7;7)(q34;q36) ZNF767P/BRAF
t(7;9)(q34;q34) NUP214/BRAF
t(7;10)(q34;p11) CCNY/BRAF
t(7;10)(q34;q21) CCDC6/BRAF
t(7;12)(q34;p11) CCDC91/BRAF
t(7;12)(q34;p13) ERC1/BRAF
t(7;13)(q34;q21) MZT1/BRAF
t(7;15)(q34;q24) ETFA/BRAF
t(7;16)(q34;p13) BRAF/CIITA
t(7;17)(q34;p11) TOM1L2/BRAF
t(7;17)(q34;q21) CDC27/BRAF
t(7;17)(q34;q21) RUNDC1/BRAF
t(7;19)(q34;q13) CEP89/BRAF
t(7;19)(q34;q13) LSM14A/BRAF


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 2 ]
  LEOPARD syndrome Noonan syndrome


External links

Nomenclature
HGNC (Hugo)BRAF   1097
LRG (Locus Reference Genomic)LRG_299
Cards
AtlasBRAFID828
Entrez_Gene (NCBI)BRAF  673  B-Raf proto-oncogene, serine/threonine kinase
AliasesB-RAF1; B-raf; BRAF1; NS7; 
RAFB1
GeneCards (Weizmann)BRAF
Ensembl hg19 (Hinxton)ENSG00000157764 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157764 [Gene_View]  ENSG00000157764 [Sequence]  chr7:140732564-140924928 [Contig_View]  BRAF [Vega]
ICGC DataPortalENSG00000157764
TCGA cBioPortalBRAF
AceView (NCBI)BRAF
Genatlas (Paris)BRAF
WikiGenes673
SOURCE (Princeton)BRAF
Genetics Home Reference (NIH)BRAF
Genomic and cartography
GoldenPath hg38 (UCSC)BRAF  -     chr7:140732564-140924928 -  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BRAF  -     7q34   [Description]    (hg19-Feb_2009)
GoldenPathBRAF - 7q34 [CytoView hg19]  BRAF - 7q34 [CytoView hg38]
ImmunoBaseENSG00000157764
Mapping of homologs : NCBIBRAF [Mapview hg19]  BRAF [Mapview hg38]
OMIM115150   163950   164757   211980   613706   613707   
Gene and transcription
Genbank (Entrez)AA252358 AA834931 AA975673 AI203435 AJ276310
RefSeq transcript (Entrez)NM_001354609 NM_004333
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BRAF
Cluster EST : UnigeneHs.684552 [ NCBI ]
CGAP (NCI)Hs.684552
Alternative Splicing GalleryENSG00000157764
Gene ExpressionBRAF [ NCBI-GEO ]   BRAF [ EBI - ARRAY_EXPRESS ]   BRAF [ SEEK ]   BRAF [ MEM ]
Gene Expression Viewer (FireBrowse)BRAF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)673
GTEX Portal (Tissue expression)BRAF
Human Protein AtlasENSG00000157764-BRAF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15056   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15056  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15056
Splice isoforms : SwissVarP15056
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP15056
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RBD (PS50898)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    Kinase-like_dom_sf    PE/DAG-bd    Prot_kinase_dom    Protein_kinase_ATP_BS    RBD_dom    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)C1_1 (PF00130)    Pkinase_Tyr (PF07714)    RBD (PF02196)   
Domain families : Pfam (NCBI)pfam00130    pfam07714    pfam02196   
Domain families : Smart (EMBL)C1 (SM00109)  RBD (SM00455)  S_TKc (SM00220)  
Conserved Domain (NCBI)BRAF
DMDM Disease mutations673
Blocks (Seattle)BRAF
PDB (RSDB)1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
PDB Europe1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
PDB (PDBSum)1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
PDB (IMB)1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
Structural Biology KnowledgeBase1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
SCOP (Structural Classification of Proteins)1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
CATH (Classification of proteins structures)1UWH    1UWJ    2FB8    2L05    3C4C    3D4Q    3IDP    3II5    3NY5    3OG7    3PPJ    3PPK    3PRF    3PRI    3PSB    3PSD    3Q4C    3Q96    3SKC    3TV4    3TV6    4CQE    4DBN    4E26    4E4X    4EHE    4EHG    4FC0    4FK3    4G9C    4G9R    4H58    4JVG    4KSP    4KSQ    4MBJ    4MNE    4MNF    4PP7    4R5Y    4RZV    4RZW    4WO5    4XV1    4XV2    4XV3    4XV9    4YHT    5C9C    5CSW    5CSX    5CT7    5FD2    5HI2    5HID    5HIE    5ITA    5J17    5J18    5J2R    5JRQ    5JSM    5JT2    5VAL    5VAM    5VYK    6B8U    6CAD   
SuperfamilyP15056
Human Protein Atlas [tissue]ENSG00000157764-BRAF [tissue]
Peptide AtlasP15056
HPRD01264
IPIIPI00303797   IPI00976947   IPI00945692   IPI00945505   IPI00946013   
Protein Interaction databases
DIP (DOE-UCLA)P15056
IntAct (EBI)P15056
FunCoupENSG00000157764
BioGRIDBRAF
STRING (EMBL)BRAF
ZODIACBRAF
Ontologies - Pathways
QuickGOP15056
Ontology : AmiGOMAPK cascade  MAPK cascade  activation of MAPKK activity  myeloid progenitor cell differentiation  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  calcium ion binding  protein binding  ATP binding  nucleus  mitochondrion  cytosol  cytosol  cytosol  plasma membrane  plasma membrane  protein phosphorylation  visual learning  animal organ morphogenesis  positive regulation of gene expression  negative regulation of fibroblast migration  positive regulation of glucose transmembrane transport  thyroid gland development  small GTPase binding  mitogen-activated protein kinase kinase binding  positive regulation of peptidyl-serine phosphorylation  somatic stem cell population maintenance  cellular response to drug  regulation of cell proliferation  identical protein binding  neuron projection  negative regulation of apoptotic process  intracellular membrane-bounded organelle  CD4-positive, alpha-beta T cell differentiation  CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  response to peptide hormone  negative regulation of neuron apoptotic process  cell body  regulation of T cell differentiation  protein heterodimerization activity  thymus development  positive regulation of axon regeneration  positive regulation of axonogenesis  T cell receptor signaling pathway  protein heterooligomerization  positive regulation of stress fiber assembly  response to cAMP  long-term synaptic potentiation  head morphogenesis  face development  positive regulation of ERK1 and ERK2 cascade  trehalose metabolism in response to stress  cellular response to calcium ion  establishment of protein localization to membrane  positive regulation of substrate adhesion-dependent cell spreading  cellular response to nerve growth factor stimulus  negative regulation of synaptic vesicle exocytosis  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIMAPK cascade  MAPK cascade  activation of MAPKK activity  myeloid progenitor cell differentiation  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  calcium ion binding  protein binding  ATP binding  nucleus  mitochondrion  cytosol  cytosol  cytosol  plasma membrane  plasma membrane  protein phosphorylation  visual learning  animal organ morphogenesis  positive regulation of gene expression  negative regulation of fibroblast migration  positive regulation of glucose transmembrane transport  thyroid gland development  small GTPase binding  mitogen-activated protein kinase kinase binding  positive regulation of peptidyl-serine phosphorylation  somatic stem cell population maintenance  cellular response to drug  regulation of cell proliferation  identical protein binding  neuron projection  negative regulation of apoptotic process  intracellular membrane-bounded organelle  CD4-positive, alpha-beta T cell differentiation  CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  response to peptide hormone  negative regulation of neuron apoptotic process  cell body  regulation of T cell differentiation  protein heterodimerization activity  thymus development  positive regulation of axon regeneration  positive regulation of axonogenesis  T cell receptor signaling pathway  protein heterooligomerization  positive regulation of stress fiber assembly  response to cAMP  long-term synaptic potentiation  head morphogenesis  face development  positive regulation of ERK1 and ERK2 cascade  trehalose metabolism in response to stress  cellular response to calcium ion  establishment of protein localization to membrane  positive regulation of substrate adhesion-dependent cell spreading  cellular response to nerve growth factor stimulus  negative regulation of synaptic vesicle exocytosis  negative regulation of endothelial cell apoptotic process  
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    FoxO signaling pathway    mTOR signaling pathway    Vascular smooth muscle contraction    Focal adhesion    Natural killer cell mediated cytotoxicity    Long-term potentiation    Neurotrophin signaling pathway    Serotonergic synapse    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    Progesterone-mediated oocyte maturation    Alcoholism    Hepatitis C    Pathways in cancer    Proteoglycans in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
REACTOMEP15056 [protein]
REACTOME PathwaysR-HSA-6802955 [pathway]   
NDEx NetworkBRAF
Atlas of Cancer Signalling NetworkBRAF
Wikipedia pathwaysBRAF
Orthology - Evolution
OrthoDB673
GeneTree (enSembl)ENSG00000157764
Phylogenetic Trees/Animal Genes : TreeFamBRAF
HOGENOMP15056
Homologs : HomoloGeneBRAF
Homology/Alignments : Family Browser (UCSC)BRAF
Gene fusions - Rearrangements
Fusion : MitelmanAGTRAP/BRAF [1p36.22/7q34]  [t(1;7)(p36;q34)]  
Fusion : MitelmanAKAP9/BRAF [7q21.2/7q34]  [inv(7)(q21q34)]  
Fusion : MitelmanAP3B1/BRAF [5q14.1/7q34]  [t(5;7)(q14;q34)]  
Fusion : MitelmanATG7/BRAF [3p25.3/7q34]  [t(3;7)(p25;q34)]  
Fusion : MitelmanBRAF/AP3B1 [7q34/5q14.1]  [t(5;7)(q14;q34)]  
Fusion : MitelmanBRAF/ATG7 [7q34/3p25.3]  [t(3;7)(p25;q34)]  
Fusion : MitelmanBRAF/CIITA [7q34/16p13.13]  [t(7;16)(q34;p13)]  
Fusion : MitelmanBRAF/FAM114A2 [7q34/5q33.2]  [t(5;7)(q33;q34)]  
Fusion : MitelmanBRAF/HIBADH [7q34/7p15.2]  [t(7;7)(p15;q34)]  
Fusion : MitelmanBRAF/MACF1 [7q34/1p34.3]  [t(1;7)(p34;q34)]  
Fusion : MitelmanBRAF/SLC26A4 [7q34/7q22.3]  [t(7;7)(q22;q34)]  
Fusion : MitelmanBRAF/SND1 [7q34/7q32.1]  [t(7;7)(q32;q34)]  
Fusion : MitelmanBRAF/SUGCT [7q34/7p14.1]  [t(7;7)(p14;q34)]  
Fusion : MitelmanCCNY/BRAF [10p11.21/7q34]  [t(7;10)(q34;p11)]  
Fusion : MitelmanCDC27/BRAF [17q21.32/7q34]  [t(7;17)(q34;q21)]  
Fusion : MitelmanCLCN6/BRAF [1p36.22/7q34]  [t(1;7)(p36;q34)]  
Fusion : MitelmanERC1/BRAF [12p13.33/7q34]  [t(7;12)(q34;p13)]  
Fusion : MitelmanFAM114A2/BRAF [5q33.2/7q34]  [t(5;7)(q33;q34)]  
Fusion : MitelmanFCHSD1/BRAF [5q31.3/7q34]  [t(5;7)(q31;q34)]  
Fusion : MitelmanFXR1/BRAF [3q26.33/7q34]  [t(3;7)(q26;q34)]  
Fusion : MitelmanGNAI1/BRAF [7q21.11/7q34]  [t(7;7)(q21;q34)]  
Fusion : MitelmanHIBADH/BRAF [7p15.2/7q34]  [t(7;7)(p15;q34)]  
Fusion : MitelmanMACF1/BRAF [1p34.3/7q34]  [t(1;7)(p34;q34)]  
Fusion : MitelmanNRF1/BRAF [7q32.2/7q34]  [t(7;7)(q32;q34)]  
Fusion : MitelmanRNF130/BRAF [5q35.3/7q34]  [t(5;7)(q35;q34)]  
Fusion : MitelmanSLC45A3/BRAF [1q32.1/7q34]  [t(1;7)(q32;q34)]  
Fusion : MitelmanSND1/BRAF [7q32.1/7q34]  [t(7;7)(q32;q34)]  
Fusion : MitelmanTAX1BP1/BRAF [7p15.2/7q34]  [t(7;7)(p15;q34)]  
Fusion : COSMICAGTRAP [1p36.22]  -  BRAF [7q34]  [fusion_828]  [fusion_829]  
Fusion : COSMICAKAP9 [7q21.2]  -  BRAF [7q34]  [fusion_1013]  [fusion_1014]  [fusion_1017]  
Fusion : COSMICBRAF [7q34]  -  AKAP9 [7q21.2]  [fusion_1015]  [fusion_1016]  
Fusion : COSMICCEP89 [19q13.11]  -  BRAF [7q34]  [fusion_1649]  [fusion_1650]  
Fusion : COSMICCLCN6 [1p36.22]  -  BRAF [7q34]  [fusion_1440]  [fusion_1441]  
Fusion : COSMICFAM131B [7q34]  -  BRAF [7q34]  [fusion_1189]  [fusion_1190]  [fusion_1191]  [fusion_1192]  [fusion_1193]  [fusion_1194]  [fusion_1611]  
Fusion : COSMICFCHSD1 [5q31.3]  -  BRAF [7q34]  [fusion_403]  [fusion_404]  
Fusion : COSMICGATM [15q21.1]  -  BRAF [7q34]  [fusion_1730]  [fusion_1731]  
Fusion : COSMICGNAI1 [7q21.11]  -  BRAF [7q34]  [fusion_1442]  [fusion_1443]  
Fusion : COSMICHERPUD1 [16q13]  -  BRAF [7q34]  [fusion_1726]  [fusion_1727]  
Fusion : COSMICKIAA1549 [7q34]  -  BRAF [7q34]  [fusion_1226]  [fusion_1227]  [fusion_1228]  [fusion_1229]  [fusion_1283]  [fusion_1284]  [fusion_1471]  
[fusion_1472]  [fusion_1474]  [fusion_1475]  [fusion_1476]  [fusion_1477]  [fusion_481]  [fusion_482]  [fusion_483]  [fusion_484]  [fusion_485]  
[fusion_486]  [fusion_509]  [fusion_510]  [fusion_511]  [fusion_512]  [fusion_588]  
Fusion : COSMICLSM14A [19q13.11]  -  BRAF [7q34]  [fusion_1651]  [fusion_1652]  
Fusion : COSMICMKRN1 [7q34]  -  BRAF [7q34]  [fusion_1444]  [fusion_1445]  
Fusion : COSMICRNF130 [5q35.3]  -  BRAF [7q34]  [fusion_1483]  [fusion_1484]  
Fusion : COSMICSLC45A3 [1q32.1]  -  BRAF [7q34]  [fusion_871]  [fusion_872]  
Fusion : COSMICSND1 [7q32.1]  -  BRAF [7q34]  [fusion_1714]  [fusion_1715]  [fusion_1716]  [fusion_1718]  [fusion_1719]  [fusion_1721]  [fusion_1722]  
[fusion_1723]  [fusion_1724]  [fusion_1725]  
Fusion : COSMICZSCAN30 [18q12.2]  -  BRAF [7q34]  [fusion_1728]  [fusion_1729]  
Fusion PortalAGK 7q34 BRAF 7q34 THCA
Fusion PortalATG7 3p25.3 BRAF 7q34 SKCM
Fusion PortalBCL2L11 2q13 BRAF 7q34 THCA
Fusion PortalBRAF 7q34 AGK 7q34 THCA
Fusion PortalBRAF 7q34 AP3B1 5q14.1 THCA
Fusion PortalBRAF 7q34 ATG7 3p25.3 SKCM
Fusion PortalBRAF 7q34 C7orf10 THCA
Fusion PortalBRAF 7q34 CIITA 16p13.13 THCA
Fusion PortalBRAF 7q34 FAM114A2 5q33.2 THCA
Fusion PortalBRAF 7q34 HIBADH 7p15.2 SKCM
Fusion PortalBRAF 7q34 MACF1 1p34.3 THCA
Fusion PortalBRAF 7q34 MRPS33 7q34 BLCA
Fusion PortalBRAF 7q34 SLC26A4 7q22.3 LUSC
Fusion PortalBRAF 7q34 SND1 7q32.1 THCA
Fusion PortalC7orf73 7q33 BRAF 7q34 PRAD
Fusion PortalCCNY 10p11.21 BRAF 7q34 THCA
Fusion PortalFAM114A2 5q33.2 BRAF 7q34 THCA
Fusion PortalHIBADH 7p15.2 BRAF 7q34 SKCM
Fusion PortalJHDM1D BRAF 7q34 PRAD
Fusion PortalKIAA1549 7q34 BRAF 7q34 LGG
Fusion PortalMACF1 1p34.3 BRAF 7q34 THCA
Fusion PortalMKRN1 7q34 BRAF 7q34 THCA
Fusion PortalSND1 7q32.1 BRAF 7q34 THCA
Fusion PortalZC3HAV1 7q34 BRAF 7q34 THCA
Fusion : TICdbFCHSD1 [5q31.3]  -  BRAF [7q34]
Fusion : FusionGDB10614    1111    1173    12488    1361    16161    18059    18723    19053    20498    2079    22113    3209    34528    35084   
37290    38743    39472    4015    42610    4352    4353    4354    4355    4356    4357    4358    4359    4360    4361   
4362    4363    4364    4365    4366    4367    4368    4369    6042    6328    9009   
Fusion : Fusion_HubAGAP3--BRAF    AGK--BRAF    AGTRAP--BRAF    AKAP9--BRAF    AKAP9_ENST00000356239--BRAF    AP3B1--BRAF    ARMC10--BRAF    ATG7--BRAF    BAIAP2L1--BRAF    BBS9--BRAF    BCAP29--BRAF    BCAS1--BRAF    BCL2L11--BRAF    BRAF--AGK    BRAF--AKAP9   
BRAF--AP3B1    BRAF--ATG7    BRAF--BAIAP2L1    BRAF--BRAF    BRAF--BRAFP1    BRAF--BTF3L4    BRAF--C7ORF10    BRAF--CCDC6    BRAF--CCDC91    BRAF--CCNY    BRAF--CDC27    BRAF--CDK5RAP2    BRAF--CEP89    BRAF--CIITA    BRAF--CLCN6   
BRAF--CREB3L2    BRAF--CSGALNACT1    BRAF--CUL1    BRAF--CUX1    BRAF--DENND2A    BRAF--DLG1    BRAF--DSC3    BRAF--DYNC1I2    BRAF--EFTUD1    BRAF--EML4    BRAF--EPS15    BRAF--ERC1    BRAF--ESYT2    BRAF--ETFA    BRAF--FAM114A2   
BRAF--FAM120B    BRAF--FAM131A    BRAF--FAM131B    BRAF--FBXL17    BRAF--FCHSD1    BRAF--FXR1    BRAF--GATM    BRAF--GHR    BRAF--GIPC2    BRAF--GNAI1    BRAF--GTF2I    BRAF--HERPUD1    BRAF--HIBADH    BRAF--JHDM1D    BRAF--KDM7A   
BRAF--KIAA1549    BRAF--KLHL7    BRAF--KMT2E    BRAF--LSM14A    BRAF--MACF    BRAF--MACF1    BRAF--MALSU1    BRAF--MKRN1    BRAF--MRPS33    BRAF--MYRIP    BRAF--MZT1    BRAF--NFYA    BRAF--NRF1    BRAF--NUB1    BRAF--NUP214   
BRAF--OSBPL9    BRAF--PAPSS1    BRAF--PHTF2    BRAF--PICALM    BRAF--PJA2    BRAF--POR    BRAF--PRKAR1B    BRAF--PRKAR2B    BRAF--QKI    BRAF--RAD18    BRAF--RBM33    BRAF--RBMS3    BRAF--RNF130    BRAF--RNF38    BRAF--RNPC3   
BRAF--RUNDC1    BRAF--SCAF8    BRAF--SCRIB    BRAF--SEPT7    BRAF--SLC12A7    BRAF--SLC25A37    BRAF--SLC26A4    BRAF--SLC45A3    BRAF--SND1    BRAF--STK17A    BRAF--STK35    BRAF--STRN3    BRAF--STXBP3    BRAF--STXBP6    BRAF--SVOPL   
BRAF--TANK    BRAF--TAX1BP1    BRAF--TLK2    BRAF--TMEM106B    BRAF--TNS3    BRAF--TOM1L2    BRAF--TRIM24    BRAF--TRIM4    BRAF--TTC26    BRAF--UBN2    BRAF--ZC3HAV1    BRAF--ZKSCAN1    BRAF--ZNF207    BRAF--ZNF767    BRAF--ZSCAN23   
BRAF--ZSCAN30    C7ORF73--BRAF    CCNY--BRAF    CDC27--BRAF    CEP89--BRAF    CLCN6--BRAF    CLIP1--BRAF    CSGALNACT2--BRAF    CUL1--BRAF    CUX1--BRAF    DSTYK--BRAF    EML4--BRAF    ETV1--BRAF    FAM114A2--BRAF    FAM131B--BRAF   
FAM131B_ENST00000443739--BRAF    FCHSD1--BRAF    GATM--BRAF    GNAI1--BRAF    HERPUD1--BRAF    HIBADH--BRAF    JHDM1D--BRAF    KIAA1549--BRAF    KIDINS220--BRAF    KRAS--BRAF    LSM12--BRAF    LSM14A--BRAF    MACF--BRAF    MACF1--BRAF    MBP--BRAF   
MKRN1--BRAF    NRAS--BRAF    NRF1--BRAF    OSBPL9--BRAF    PIAS1--BRAF    POR--BRAF    RNF130--BRAF    SDK1--BRAF    SEPT7--BRAF    SF1--BRAF    SLC45A3--BRAF    SND1--BRAF    STXBP6--BRAF    TAX1BP1--BRAF    TGFBR2--BRAF   
TMPRSS2--BRAF    TNRC6B--BRAF    TRIM24--BRAF    TRIM4--BRAF    UBN2--BRAF    WDFY3--BRAF    ZBTB8A--BRAF    ZC3HAV1--BRAF    ZFC3H1--BRAF    ZSCAN30--BRAF   
Fusion : QuiverBRAF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRAF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRAF
dbVarBRAF
ClinVarBRAF
1000_GenomesBRAF 
Exome Variant ServerBRAF
ExAC (Exome Aggregation Consortium)ENSG00000157764
GNOMAD BrowserENSG00000157764
Varsome BrowserBRAF
Genetic variants : HAPMAP673
Genomic Variants (DGV)BRAF [DGVbeta]
DECIPHERBRAF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBRAF 
Mutations
ICGC Data PortalBRAF 
TCGA Data PortalBRAF 
Broad Tumor PortalBRAF
OASIS PortalBRAF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRAF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRAF
intOGen PortalBRAF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)SpainMDB
BioMutasearch BRAF
DgiDB (Drug Gene Interaction Database)BRAF
DoCM (Curated mutations)BRAF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRAF (select a term)
intoGenBRAF
NCG5 (London)BRAF
Cancer3DBRAF(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM115150    163950    164757    211980    613706    613707   
Orphanet206    905    1032    1559    19659    19659    10778    10756    14445   
DisGeNETBRAF
MedgenBRAF
Genetic Testing Registry BRAF
NextProtP15056 [Medical]
TSGene673
GENETestsBRAF
Target ValidationBRAF
Huge Navigator BRAF [HugePedia]
snp3D : Map Gene to Disease673
BioCentury BCIQBRAF
ClinGenBRAF (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD673
Chemical/Pharm GKB GenePA25408
Drug Sensitivity BRAF
Clinical trialBRAF
Miscellaneous
canSAR (ICR)BRAF (select the gene name)
DataMed IndexBRAF
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=BRAF
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRAF
EVEXBRAF
GoPubMedBRAF
iHOPBRAF
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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