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CARS (cysteinyj-tRNA synthetase)

Written2003-08Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other aliascysteine-tRNA ligase
LocusID (NCBI) 833
Atlas_Id 484
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at and ends at bp from pter
Local_order 700 kb telomeric to NUP98
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALK (2p23.2) / CARS (11p15.4)CARS (11p15.4) / ALK (2p23.2)CARS (11p15.4) / OSBPL5 (11p15.4)
GRAMD1A (19q13.11) / CARS (11p15.4)MCM3 (6p12.2) / CARS (11p15.4)MIR5095 (1p32.3) / CARS (11p15.4)
NAP1L4 (11p15.4) / CARS (11p15.4)


Description The gene spans 57 kb; 22 exons; 2,5 kb cDNA
Transcription alternate splicing


Description 748 amino acids, 85 kDa. Forms homodimers
Localisation cytoplasmic

Implicated in

Entity Inflammatory myofibroblastic tumors with a complex t(2;11)(p23;p15)
Disease rare soft tissue tumour found in children and young adults
Prognosis good prognosis
Hybrid/Mutated Gene 5' CARS - 3' ALK
Abnormal Protein N-term CARS (606 amino acids) fused to the usual 562 C-term amino acids of ALK


Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.
Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, De Wolf-Peeters C, Pauwels P, Hagemeijer A, Marynen P
Genes, chromosomes & cancer. 2002 ; 34 (4) : 354-362.
PMID 12112524


This paper should be referenced as such :
Huret, JL ; Senon, S
CARS (cysteinyj-tRNA synthetase)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(4):221-221.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Soft Tissues: Inflammatory myofibroblastic tumor
Soft Tissues: Inflammatory myofibroblastic tumor with t(2;11)(p23;p15) CARS/ALK
CARS/OSBPL5 (11p15)
NAP1L4/CARS (11p15)

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)833
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 21:06:42 CET 2019

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