CDX2 (caudal-related homeobox 2)
2000-04-01 Nick CP Cross AffiliationWessex Regional Genetics Laboratory Salisbury District Hospital Salisbury, SP2 8BJ, UK
Identity
HGNC
LOCATION
13q12.2
IMAGE
LEGEND
CDX2 (13q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
CDX-3,CDX2/AS,CDX3
FUSION GENES
DNA/RNA
Description
Three exons transcribed from telomere to centromere.
Proteins
Expression
Nuclear protein normally expressed almost exclusively in the intestine, where it plays a role in the proliferation and differentiation of intestinal epithelial cells.
Mutations
Somatic
Found to be mutated in rare cases of colorectal carcinoma
Implicated in
Entity name
Fusion protein
Fusion of ETV6 exon 2 to CDX2 exon 2. The predicted protein contains the N-terminal region of ETV6 38 fused to the entire homeobox of CDX2. The single case described that harbours this fusion also expressed normal CDX2, which is not normally expressed in haemopoietic cells.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9920852 | 1999 | Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). | Chase A et al |
| 9459001 | 1997 | Cloning and chromosome assignment of the human CDX2 gene. | Drummond F et al |
| 9704932 | 1998 | CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. | Wicking C et al |
| 10490837 | 1999 | CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. | da Costa LT et al |
Other Information
Locus ID:
NCBI: 1045
MIM: 600297
HGNC: 1806
Ensembl: ENSG00000165556
Variants:
dbSNP: 1045
ClinVar: 1045
TCGA: ENSG00000165556
COSMIC: CDX2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000165556 | ENST00000381020 | Q99626 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37583001 | 2024 | Loss of SATB2 and CDX2 expression is associated with DNA mismatch repair protein deficiency and BRAF mutation in colorectal cancer. | 0 |
| 38295844 | 2024 | CDX2 alleviates hypoxia-induced apoptosis and oxidative stress in spermatogenic cells through suppression of reactive oxygen species-mediated Wnt/β-catenin pathway. | 0 |
| 38514066 | 2024 | Combined Use of Helicobacter pylori Genotyping and CDX2 Expression as a Predictor of Malignant Potential in Gastric Intestinal Metaplasia. | 0 |
| 38555678 | 2024 | Concomitant expression patterns of CDX2 and SATB2 as prognostic factors in stage III colorectal cancers. | 0 |
| 37583001 | 2024 | Loss of SATB2 and CDX2 expression is associated with DNA mismatch repair protein deficiency and BRAF mutation in colorectal cancer. | 0 |
| 38295844 | 2024 | CDX2 alleviates hypoxia-induced apoptosis and oxidative stress in spermatogenic cells through suppression of reactive oxygen species-mediated Wnt/β-catenin pathway. | 0 |
| 38514066 | 2024 | Combined Use of Helicobacter pylori Genotyping and CDX2 Expression as a Predictor of Malignant Potential in Gastric Intestinal Metaplasia. | 0 |
| 38555678 | 2024 | Concomitant expression patterns of CDX2 and SATB2 as prognostic factors in stage III colorectal cancers. | 0 |
| 36448218 | 2023 | A novel IRF2BP2::CDX2 Gene fusion in digital intravascular myoepithelioma of soft tissue: An enigma! | 3 |
| 36839181 | 2023 | Association between Single Nucleotide Polymorphisms Related to Vitamin D Metabolism and the Risk of Developing Asthma. | 3 |
| 36848481 | 2023 | The effect of miR-372-5p regulation on CDX1 and CDX2 in the gastric cancer cell line. | 0 |
| 36928082 | 2023 | CDX-2 expression correlates with clinical outcomes in MSI-H metastatic colorectal cancer patients receiving immune checkpoint inhibitors. | 4 |
| 37325467 | 2023 | Potential predictors for CDX2 expression loss and mismatch repair deficiency in colorectal cancer. | 0 |
| 37369952 | 2023 | Relationship between CDX2 rs11568820 and EcoRV rs4516035 polymorphisms on the vitamin D receptor gene with susceptibility to different SARS-CoV-2 variants. | 0 |
| 37602699 | 2023 | Association of CDX2 and mucin expression with chemotherapeutic benefits in patients with stage II/III gastric cancer. | 1 |
Citation
Nick CP Cross
CDX2 (caudal-related homeobox 2)
Atlas Genet Cytogenet Oncol Haematol. 2000-04-01
Online version: http://atlasgeneticsoncology.org/gene/326/cdx2
