SARNP (cytokine induced protein 29 kDa)
2005-08-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
12q13.2
LOCUSID
ALIAS
CIP29,HCC1,HSPC316,THO1
FUSION GENES
Proteins
Description
210 amino acids, 29 kDa;contains from N term to C term a SAP domain and 2 nuclear localization domains, and also 3 possible N-glycosylation sites and 9 potential phosphorylation sites. A SAP domain is a putative DNA binding motif involved in chromosomal organization and may regulate transcription, DNA repair, RNA processing.
Expression
Localisation
Nucleus but some staining was also found in the cytoplasm.
Implicated in
Entity name
Note
only one case to date
Prognosis
unknown
Hybrid gene
5 MLL - 3 CIP29 including the 9 first exons of MLL, and nearly the entire CIP29
Fusion protein
The fusion protein includes from N term to C term the AT hooks and the methyltransferase domain of MLL and the SAP domain and the C term nuclear localization domains of CIP29.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15924260 | 2005 | Growth inhibitory effect of Hcc-1/CIP29 is associated with induction of apoptosis, not just with G2/M arrest. | Fukuda S et al |
| 11922608 | 2002 | Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29. | Fukuda S et al |
| 15284855 | 2004 | A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia. | Hashii Y et al |
Other Information
Locus ID:
NCBI: 84324
MIM: 610049
HGNC: 24432
Ensembl: ENSG00000205323
Variants:
dbSNP: 84324
ClinVar: 84324
TCGA: ENSG00000205323
COSMIC: SARNP
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000205323 | ENST00000336133 | P82979 |
| ENSG00000205323 | ENST00000546604 | P82979 |
| ENSG00000205323 | ENST00000552080 | F8VZQ9 |
| ENSG00000205323 | ENST00000552884 | F8VS12 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37578863 | 2023 | Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. | 3 |
| 37578863 | 2023 | Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. | 3 |
| 31313837 | 2020 | SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin. | 11 |
| 31313837 | 2020 | SARNP, a participant in mRNA splicing and export, negatively regulates E-cadherin expression via interaction with pinin. | 11 |
| 27189710 | 2016 | Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29. | 4 |
| 27189710 | 2016 | Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29. | 4 |
| 17196963 | 2007 | Intracellular characterization of DDX39, a novel growth-associated RNA helicase. | 33 |
| 17196963 | 2007 | Intracellular characterization of DDX39, a novel growth-associated RNA helicase. | 33 |
| 15338056 | 2004 | Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. | 14 |
| 15338056 | 2004 | Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. | 14 |
| 11922608 | 2002 | Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29. | 15 |
| 11922608 | 2002 | Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29. | 15 |
Citation
Jean-Loup Huret ; Sylvie Senon
SARNP (cytokine induced protein 29 kDa)
Atlas Genet Cytogenet Oncol Haematol. 2005-08-01
Online version: http://atlasgeneticsoncology.org/gene/42967/sarnp
