COX6C (cytochrome c oxidase subunit VIc)
2004-04-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Description
The gene spans 15.5 kb; orientation : reverse strand; 4 exons; this cytochrome C oxidase subunit 6c is encoded by the nuclear DNA (some other subunits are encoded by the mitochondrial DNA).
Proteins
Expression
wide
Localisation
mitochondria (inner membrane)
Function
subunit of the cytochrome C oxidase (respiratory chain complex of the mitochondria); catalytic activity.
Implicated in
Entity name
Uterine fibromyoma
Disease
The most common benign tumors of the female genital tract.
Hybrid gene
HMGA2 HMGA2 exon 3 was found fused to COX6C exon 2 in one case without cytogenetic analysis; HMGA2 (previously named HMGIC), sitting in 12q15, is the most frequently involved gene in uterine leiomyoma.
Fusion protein
The 3 N-term DNA binding domains (AT hooks) of HMGA2 is fused to the C-term of COX6C
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10679920 | 2000 | Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma. | Kurose K et al |
| 9752724 | 1998 | Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. | Lenka N et al |
Other Information
Locus ID:
NCBI: 1345
MIM: 124090
HGNC: 2285
Ensembl: ENSG00000164919
Variants:
dbSNP: 1345
ClinVar: 1345
TCGA: ENSG00000164919
COSMIC: COX6C
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38242874 | 2024 | COX6C expression driven by copy amplification of 8q22.2 regulates cell proliferation via mediation of mitosis by ROS-AMPK signaling in lung adenocarcinoma. | 1 |
| 38242874 | 2024 | COX6C expression driven by copy amplification of 8q22.2 regulates cell proliferation via mediation of mitosis by ROS-AMPK signaling in lung adenocarcinoma. | 1 |
| 29505834 | 2018 | Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation. | 5 |
| 29505834 | 2018 | Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation. | 5 |
| 25203353 | 2014 | Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276. | 29 |
| 25203353 | 2014 | Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276. | 29 |
| 22860893 | 2013 | Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway. | 7 |
| 22860893 | 2013 | Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway. | 7 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 19843159 | 2009 | Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria. | 47 |
| 19843159 | 2009 | Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria. | 47 |
| 19064571 | 2008 | Polymorphisms in mitochondrial genes and prostate cancer risk. | 22 |
| 19064571 | 2008 | Polymorphisms in mitochondrial genes and prostate cancer risk. | 22 |
Citation
Jean-Loup Huret ; Sylvie Senon
COX6C (cytochrome c oxidase subunit VIc)
Atlas Genet Cytogenet Oncol Haematol. 2004-04-01
Online version: http://atlasgeneticsoncology.org/gene/251/cox6c
