DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10

1998-01-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
11q22.3
IMAGE
Atlas Image
LEGEND
DDX10 (11q22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
Dbp4,HRH-J8
FUSION GENES

DNA/RNA

Description

at least 12 exons; spans more than a 200-kb region

Transcription

alternative splicing; 3.2 and 5.0 kb mRNA

Proteins

Description

contains 2 nuclear localization signals (NLS), a DEAD box (DEAD for: ASP-GLU_ALA-ASP)

Expression

wide

Localisation

nucleolus (probable)

Function

putative ATP-dependent DEAD box RNA helicase; possible role in ribosome assembly through rRNA processing

Homology

SPB4 and DRS1 (yeast)

Implicated in

Entity name
inv (11)(p15q22)/MDS or AML --> NUP98- DDX10
Disease
therapy related MDS and AML; de novo AML
Hybrid gene
5 NUP98 - 3 DDX10
Fusion protein
fuses the GLFG repeat domains of NUP98 to the charged amino acids domain of DDX11

Bibliography

Pubmed IDLast YearTitleAuthors
91668301997The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.Arai Y et al
86609681996A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.Savitsky K et al

Other Information

Locus ID:

NCBI: 1662
MIM: 601235
HGNC: 2735
Ensembl: ENSG00000178105

Variants:

dbSNP: 1662
ClinVar: 1662
TCGA: ENSG00000178105
COSMIC: DDX10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178105ENST00000322536Q13206
ENSG00000178105ENST00000526794E9PIF2
ENSG00000178105ENST00000648124A0A3B3ISR7

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193325562009A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4.33
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
267133672016Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-κB pathway in ovarian cancer.3
307385792019DDX10 overexpression predicts worse prognosis in osteosarcoma and its deletion prohibits cell activities modulated by MAPK pathway.3

Citation

Jean-Loup Huret

DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10

Atlas Genet Cytogenet Oncol Haematol. 1998-01-01

Online version: http://atlasgeneticsoncology.org/gene/35/ddx10